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Febuxostat

Febuxostat Suppliers list
Company Name: Beijing Cooperate Pharmaceutical Co.,Ltd.
Tel: +86-10-60279497 +86(0)15646567669
Email: sales01@cooperate-pharm.com
Products Intro: Product Name:Febuxostat
CAS:144060-53-7
Purity:98% Package:100G;1KG;5KG;10KG;25KG;50KG;100KG
Company Name: Shenzhen Sendi Biotechnology Co.Ltd.
Tel: 0755-23311925 18102838259
Email: Abel@chembj.com
Products Intro: Product Name:Febuxostat
CAS:144060-53-7
Purity:99% Package:2090/KG
Company Name: Shenyang NovPharm Technology Co., Ltd.  Gold
Tel:+86 (24) 2416-5786
Email:novpharm@hotmail.com;xiaochu812@hotmail.com
Products Intro:Purity:≥99%; Individual Impurity≤0.1% Package:25 Kg/drum
Company Name: Accendatech Co., LTD.  Gold
Tel:022-83718541 022-83718543
Email:sales@accendatech.com, chuanjiang.qiu@accendatech.com
Products Intro:Product Name:Febuxostat
CAS:144060-53-7
Purity:>99% Package:5g;10g;25g; Remarks:B1060001
Company Name: Beijing Lianben Pharm-Chemicals Tech. Co., Ltd  Gold
Tel:+86-10-83386766
Email:sales@lianben.com
Products Intro:Product Name:Febuxostat
CAS:144060-53-7
Package:On Request
Febuxostat Basic information
Indications and Usage Mechanisms of Action
Product Name:Febuxostat
Synonyms:Febuxostat (Uloric);FBX;Uloric;Febuxostat (TEI-6720);Febuxostat Tablets;FEBUXOSTAT API;Febuxostat (This product is unavailable in the U.S.);Febuxostat Tabletshehe
CAS:144060-53-7
MF:C16H16N2O3S
MW:316.37
EINECS:
Product Categories:zjh;API;Febuxostat;TRILIPIX;Other APIs;eterocycles;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:144060-53-7.mol
Febuxostat Structure
Febuxostat Chemical Properties
Melting point 238-239°(dec.)
storage temp. Refrigerator
CAS DataBase Reference144060-53-7(CAS DataBase Reference)
Safety Information
MSDS Information
Febuxostat Usage And Synthesis
Indications and UsageFebuxostat is a new generation xanthine oxidase inhibitor developed by Tejin Co. (Japan,) used clinically for for long-term treatment of hyperuicemia (gout,) a new and highly effective non-purine selective inhibitor of xanthine oxidase. It is not recommended for gout patients without hyperuricemia.
Mechanisms of ActionThe production of uric acid in the body is related to purine metabolism. In the last step of the production, hypoxanthine produces xanthine through the action of xanthine oxidoreductase (XOR), finally producing uric acid. Inhibiting the activity of this enzyme can effectively reduce the production of uric acid. Xanthine oxidase is the main enzyme promoting uric acid production. Through highly selective inhibition of oxidized and reduced xanthine oxidase, Febuxostat can reduce synthesis of uric acid, decreasing its concentration and effectively treating gout . Through liver metabolism, Xanthine oxidase does not rely on renal excretion, so patients with moderate to severe liver and kidney dysfunction do not need to reduce dosages. Febuxostat is a non-purine XOR inhibitor, so it is very safe.
Chemical PropertiesCrystalline Solid
Usesantihyperlipidemic
UsesXanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.
UsesFebuxostat is primarily indicated in conditions like Gout, Hyperuricemia
Febuxostat Preparation Products And Raw materials
Tag:Febuxostat(144060-53-7) Related Product Information
ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate 4-(2-THIAZOLYL)PHENOL 2-Methoxy-5-methylbenzonitrile 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID (4-METHYL-2-PHENYL-1,3-THIAZOL-5-YL)METHANOL 2-Ethoxybenzonitrile Febuxostat 5-Chloro-2-methyl-3(2H)-isothiazolone with 2-methyl-3(2H)-isothiazolone Methyl salicylate Lithium tri-tert-butoxyaluminum hydride Thiophanate-methyl Methyl bromide Ethyl cyanoformate Methyl 4-cyanobenzoate Tribenuron methyl Cyano