山奈苷

山奈苷

中文名称山奈苷
中文同义词山奈苷;山奈酚-3,7-O-L-二鼠李糖苷;山奈苷(标准品);山奈酚-3,7-二鼠李糖苷;山奈苷(山奈酚-3,7-二鼠李糖苷);KAEMPFERITRIN 山奈苷;山奈苷对照品,;山奈苷, 来源于万寿菊
英文名称KAEMPFERITRIN
英文同义词KAEMPFEROL-3,7-DIRHAMNOSIDE,KaeMpferitrin;lespenefril;KAEMPFEROL-3,7-DIRHAMNOSIDE;3,7-Bis[(6-deoxy-α-L-mannopyranosyl)oxy]-4',5-dihydroxyflavone;3,7-Bis[(6-deoxy-α-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;Kaempherol 3,7-bismannoside;Lespedin;3,7-bis[(6-deoxy-beta-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
CAS号482-38-2
分子式C27H30O14
分子量578.52
EINECS号
相关类别植提标准品;对照品;植物提取物;中药对照品;标准品;高纯试剂;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;标准品-中药标准品;标准品,对照品;黄酮;标准品 -中药标准品
Mol文件482-38-2.mol
结构式山奈苷 结构式

山奈苷 性质

熔点202~203℃
沸点908.6±65.0 °C(Predicted)
密度1.70
储存条件-20°C
溶解度DMSO:125 mg/mL(216.07 mM;需要超声波)
形态粉末
酸度系数(pKa)5.81±0.40(Predicted)
颜色白色至米色
稳定性吸湿性

山奈苷 用途与合成方法

Kaempferitrin 是一种天然黄酮苷类化合物,具有镇痛、消炎、抗糖尿病、抗肿瘤和化疗的作用,同时可激活胰岛素 (insulin) 信号传导。

Insulin Receptor

Kaempferitrin activates insulin signaling pathway. Kaempferitrin causes survival rates higher than 90% at 1-20 μM in matured 3T3-L1 adipocyte, and the survival rates decline rapidly at 25 and 50 μM. Kaempferitrin (15 μM) increases insulin receptor beta tyrosine phosphorylation and tyrosine phosphorylation of the insulin receptor substrate 1, and such effects are similar to that of 10 nM insulin. Kaempferitrin (15 μM) also stimulates akt phosphorylation on ser473, and the stimulation can be blocked by a PI3-K inhibitor wortmannin. Kaempferitrin potently exerts the translocation of GLUT4 to the membrane of adipocytes at 15 μM, and this is suppressed by wortmannin. In addition, Kaempferitrin increases the total levels of Glu4 protein in differentiated cells and secreted adiponectin in mature 3T3-L1 adipocytes. Kaempferitrin is cytotoxic to human cancer cells such as HeLa and MDA-MB231 cells, with IC 50 s of 45 ± 2.6 and 65 ± 2.6 μM, and shows low toxic effects on non-tumorigenic cells. Kaempferitrin (45 μM) induces apoptosis of HeLa cells after treatment for 24 and 48 h, and causes reactive oxygen species (ROS) generation in HeLa cells. Furthermore, Kaempferitrin (45 μM) exerts G1 arrest, causes the expression of proteins associated with intrinsic pathway of apoptosis and activates caspase 3 in HeLa cells.

Kaempferitrin (2.5, 10 and 25 mg/kg, i.p.) markedly suppresses the growth of tumor by 40%, 87% and 97%, and decreases tumor weight by 37%, 81% and 95%, respectively in nu/nu mice bearing HeLa tumor. Kaempferitrin also inhibits cell proliferation and extends life span in mice bearing tumor.

化学性质 
黄色结晶,可溶于甲醇、乙醇、DMSO等有机溶剂,来源于鸡冠花、伞形科植物柴胡,万寿菊,山奈。
用途 
山奈苷具有降血糖、抗疲劳、清热解毒,消肿止痛的作用。
用途 
用于含量测定/鉴定/药理实验等。
药理药效:具有降血糖和抗疲劳活性,清热解毒、 消肿止痛。

安全信息

安全说明24/25
海关编码29389090

MSDS信息

更新日期产品编号产品名称CAS号包装价格
2024/01/16S9112山奈苷
Kaempferitrin
482-38-21mg1204.24元

山奈苷 上下游产品信息

"山奈苷"相关产品信息
异槲皮苷 积雪草苷 石杉碱甲 山奈素 毛异黄酮 山奈酚 莰菲醇-3-O-芸香糖苷 白皮杉醇 绞股蓝皂苷XLIX 柴胡皂苷G 黄藤素 (+)-表松脂素-4′-O-Β-D-葡萄糖苷 七叶胆苷XVII 三七皂苷FA 川陈皮素 异甘草甙 木香烃内酯 连翘脂苷B
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