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Anisole

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Products Intro: Product Name:Anisole
CAS:100-66-3
Purity:98%(Min,GC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Shanghai Kaisai Chemical Co., Ltd  Gold
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Products Intro:CAS:100-66-3
Company Name: Shanghai Aladdin Bio-Chem Technology Co.,LTD  Gold
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Products Intro:Product Name:Anisole
CAS:100-66-3
Purity:Standard for GC,>=99.5%(GC) Package:53.4RMB/5ML
Company Name: J & K SCIENTIFIC LTD.  
Tel:400-666-7788 +86-10-82848833
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Products Intro:Product Name:Anisole
CAS:100-66-3
Purity:99% Package:1L,250ML
Company Name: Meryer (Shanghai) Chemical Technology Co., Ltd.  
Tel:+86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
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Products Intro:Product Name:Anisole
CAS:100-66-3
Purity:98% Package:500Ml Remarks:B71024
Anisole Chemical Properties
Melting point -37 °C
Boiling point 154 °C(lit.)
density 0.995 g/mL at 25 °C(lit.)
vapor density 3.7 (vs air)
vapor pressure 10 mm Hg ( 42.2 °C)
refractive index n20/D 1.516(lit.)
FEMA 2097
Fp 125 °F
storage temp. Store at RT.
solubility 1.71g/l
form Liquid
color Clear colorless
Relative polarity0.198
explosive limit0.34-6.3%(V)
Water Solubility 1.6 g/L (20 ºC)
Merck 14,669
BRN 506892
Stability:Stable. Flammable. Incompatible with strong oxidizing agents.
CAS DataBase Reference100-66-3(CAS DataBase Reference)
NIST Chemistry ReferenceBenzene, methoxy-(100-66-3)
EPA Substance Registry SystemBenzene, methoxy-(100-66-3)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 10-38-20-36/37
Safety Statements 37/39-26-16-24/25
RIDADR UN 2222 3/PG 3
WGK Germany 2
RTECS BZ8050000
TSCA Yes
HazardClass 3
PackingGroup III
Hazardous Substances Data100-66-3(Hazardous Substances Data)
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
Anisole Usage And Synthesis
Product FeaturesAnisole, also known as anise ether, methoxybenzene methyl phenyl ether, is a colorless liquid with an odor of anise, sweet, naturally present in the tarragon oil, insoluble in water, soluble in alcohol, ether, acetone, soluble in benzene. It irritates the eyes and mucous membranes. It is obtained originally from distilled methyl salicylate or methoxybenzoate, is now mainly produced through the reaction of methylating agent of dimethyl sulfate with phenol in alkaline aqueous solution. Anisole is prone to start Electrophilic substitution reaction in aromatic nucleus, and condensed with formaldehyde to produce viscous oil or resin material, reacts with phosphorus trichloride to produce chlorine anisole and a small amount of o-chloro product, reacts with thionyl chloride to produce 2,4,6-trichloroanisole. In addition, anisole is heated to react with hydrobromic or hydroiodic, carbon-oxygen bond cleaves, phenol and halogenated methane is produced, which is an important method for determining methoxy group of benzene ring.
The above information is edited by the chemicalbook of Yan Yanyong.
ToxicityGRAS (FEMA).
LD50 3700 mg/kg (rat, oral).
Limited useFEMA (mg/kg): Soft drinks 9.0, cold 16, confectionery51, bakery 34.
limited in moderation (FDA§172.515,2000).
Chemical propertiesIt is a colorless liquid, with an aromatic odor, insoluble in water, soluble in alcohol, ether.
Uses1. GB2760-1996 stipulates it as allowable usable spices in food. It is mainly used for the preparation of vanilla, fennel and beer flavor.
2. It is used for analyzing the reagents, solvents, and used for preparing perfumery and enteral pesticides.
3. It is used for the production of perfumes, dyes, pharmaceuticals, pesticides, also used as a solvent.
4. It is used in organic synthesis, also used as solvents, perfume and insect repellent.
5. It is used as solvents for recrystallization, fillers of thermostat, and used for measuring refractive index, as spices and organic synthesis intermediates.
Production methodIt is produced through the reaction of methylating agent of dimethyl sulfate with phenol in alkaline aqueous solution. Phenol was mixed with sodium hydroxide solution, dimethyl sulfate was slowly added at below 10 ℃. And then heat to 40 ℃, reflux for 18h, then stand for separation of the oil and dried with anhydrous calcium chloride, vacuum distillation to obtain anisole.
It is derived by introducing the methyl chloride into the sodium phenol of liquid ammonia to react.
It is generated from heating phenol and methanol.
It is obtained from the reaction of phenol with dimethyl sulfate in the presence of sodium hydroxide.
CategoryFlammable liquid
Toxicity gradingModerate toxicity
Acute toxicityOral-rat LD50: 3700 mg/kg. Oral-Mouse LD50: 2800 mg/kg
Stimulus dataSkin-rabbit 500 mg/24 hours moderate
Flammability hazard characteristicsIn case of fire, high temperature, strong oxidants, it is combustible. Burning discharges irritative smoke.
Storage featurecomplete package, with care, warehouse ventilation, away from open flame, heat, and stored separately from oxidants
Extinguishing agentsFoam, carbon dioxide, dry sandy, soil
Chemical PropertiesClear straw colored liquid
Occupational standardsSTEL 10 mg/m3
UsesA biochemical for proteomics research.
DefinitionChEBI: A monomethoxybenzene that is benzene substituted by a methoxy group.
General DescriptionA clear straw-colored liquid with an aromatic odor. Insoluble in water and the same density as water. Vapors heavier than air. Flash point 125°F. Boiling point 307°F. Moderately toxic by ingestion. A skin irritant. Used to make perfumes, flavorings and as a solvent.
Air & Water ReactionsFlammable. Ethers tend to form unstable peroxides when exposed to oxygen. Ethyl, isobutyl, ethyl tert-butyl, and ethyl tert-pentyl ether are particularly hazardous in this respect. Ether peroxides can sometimes be observed as clear crystals deposited on containers or along the surface of the liquid. Insoluble in water
Reactivity ProfileEthers, such as Anisole can act as bases. They form salts with strong acids and addition complexes with Lewis acids. The complex between diethyl ether and boron trifluoride is an example. Ethers may react violently with strong oxidizing agents. In other reactions, which typically involve the breaking of the carbon-oxygen bond, ethers are relatively inert.
Health HazardInhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
Tag:Anisole(100-66-3) Related Product Information
Phenol Phenetole Veratraldehyde Thiophanate-methyl Methyl acetate Tribenuron methyl m-Anisyl alcohol 3-Bromoanisole 3,4-Dimethoxyphenethylamine (Trifluoromethoxy)benzene 4'-Methoxyacetophenone anisole,p-propenyl Anise oil (3-Methoxyphenyl)acetonitrile Kresoxim-methyl p-Anisaldehyde Methyl salicylate 2-[[[[(4-Methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]amino]sulfonyl]benzoic acid methyl ester