Entacapone

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Products Intro: Product Name:Entacapone
CAS:116314-67-1
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Products Intro: Product Name:Entacapone
CAS:116314-67-1
Company Name: Hangzhou Yuhao Chemical Technology Co., Ltd  
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Products Intro: Product Name:Entacapone
CAS:116314-67-1
Company Name: Hubei XinyuanShun Chemical Co., Ltd.  
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Products Intro: Product Name:2-cyano-3-(5-dihydroxyaMino-3,4-dioxo-1-cyclohexa-1,5-dienyl)-n,n-diethyl-prop-2-enaMide
CAS:116314-67-1
Purity:99% Package:1kg;5kg;10kg;25kg
Company Name: Shanghai QianYan Bio-technology Co., Ltd  
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Products Intro: Product Name:Entacapone
CAS:116314-67-1
Purity:>98% .NMR+LCMS Package:50Mg/100Mg/500Mg/1g/5g/10g/
Entacapone Basic information
Product Name:Entacapone
Synonyms:N,N-Diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide;(E)-2-Cyano-3-(3,4-dihydroxy-5-nitro-phenyl)-N,N-diethyl-prop-2-enamide;2-Cyano-N,N-diethyl-3-(3,4-dihydroxy-5-nitrophenyl)propenamide;C071192;Novartis brand of entacapone;2-Propenamide, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-
CAS:116314-67-1
MF:
MW:0
EINECS:
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Mol File:116314-67-1.mol
Entacapone Structure
Entacapone Chemical Properties
Safety Information
MSDS Information
Entacapone Usage And Synthesis
OriginatorComtan,Orion Corporation
DefinitionChEBI: Entacapone is a monocarboxylic acid amide that is N,N-diethylprop-2-enamide in which the hydrogen at position 2 is substituted by a cyano group and the hydrogen at the 3E position is substituted by a 3,4-dihydroxy-5-nitrophenyl group. It has a role as an EC 2.1.1.6 (catechol O-methyltransferase) inhibitor, an antiparkinson drug, a central nervous system drug and an antidyskinesia agent. It is a monocarboxylic acid amide, a nitrile, a member of catechols and a member of 2-nitrophenols.
Manufacturing ProcessN,N-Diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide (2- Propenamide, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl).
A solution containing 1.83 g of 3,4-dihydroxy-5-nitrobenzaldehyde, 1.5 g of N,N-diethylcyanoacetamide and catalytic amount of piperidine acetate in 40 ml of dry ethanol was refluxed over night. After cooling the solvent was evaporated in vacuo and the residue was recrystallized from waterdimethylformamide. Yield of desired product was 2.23 g (73%), melting point 153°-156°C.
Therapeutic FunctionAntiparkinsonian
Entacapone Preparation Products And Raw materials
Raw materialsPiperidine Acetate-->3-Nitro-4,5-dihydroxybenzaldehyde
Tag:Entacapone(116314-67-1) Related Product Information
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