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| | 2-Hydroxy-5-methylpyridine Basic information |
| | 2-Hydroxy-5-methylpyridine Chemical Properties |
| Melting point | 183-187 °C (lit.) | | Boiling point | 304.2±15.0 °C(Predicted) | | density | 1.053±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly) | | form | Solid | | pka | 12.43±0.10(Predicted) | | color | Pale Yellow to Light Yellow | | BRN | 107074 | | InChI | InChI=1S/C6H7NO/c1-5-2-3-6(8)7-4-5/h2-4H,1H3,(H,7,8) | | InChIKey | SOHMZGMHXUQHGE-UHFFFAOYSA-N | | SMILES | C1(=O)NC=C(C)C=C1 | | CAS DataBase Reference | 1003-68-5(CAS DataBase Reference) | | NIST Chemistry Reference | 2(1H)-pyridinone, 5-methyl-(1003-68-5) |
| | 2-Hydroxy-5-methylpyridine Usage And Synthesis |
| Chemical Properties | White Solid | | Uses | 2-Hydroxy-5-methylpyridine (cas# 1003-68-5) is a useful compound for organic synthesis. In particular it has been used for the diastereoselective preparation of cyclobutane-fused pyridinyl sulfonyl fluorides. | | Definition | ChEBI: 5-Methyl-2-pyridinol is a member of methylpyridines. | | Synthesis |
3-cyano-6-hydroxypyridine and sodium lauryl sulfate were added to a mixed solvent of n-butanol and water. Subsequently, the temperature was raised to 50 °C., and sulfuric acid water obtained by dissolving 98% sulfuric acid in water was added dropwise at the temperature. After stirring for about 20 minutes, the mixture was cooled to room temperature, and 5% Pd / C was added. The system was replaced with hydrogen, and hydrogenation was carried out at atmospheric pressure for 6 hours. After the reaction was completed, the catalyst was removed by filtration, and the solution was washed with 10% sodium hydroxide aqueous solution. After partially neutralizing to H = 5 and extraction with n-butanol, a solution of crude 3-methyl-6-hydroxypyridine in butanol was obtained. When this solution was quantified by liquid chromatography, the pass-through rate was 99.2%, and the yield of 2-hydroxy-5-methylpyridine was 83%.
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| | 2-Hydroxy-5-methylpyridine Preparation Products And Raw materials |
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