苦番紅花素
| 中文名称 | 苦番紅花素 |
|---|---|
| 中文同义词 | 苦番花素;苦藏花素;苦番紅花素;藏红花苦甙;苦番红花素;苦藏花素/苦番红花素;苦番红花素(标定对照品);苦番红花素 标准品 |
| 英文名称 | Picrocrocin |
| 英文同义词 | Picrocrocin;(R)-4-(β-D-glucopyranosiloxy)-2,6,6-trimethyl-1-cyclohexene-1-carbaldehyde;(R)-4-(β-D-Glucopyranosyloxy)-2,6,6-trimethyl-1-cyclohexene-1-carbaldehyde;Saffron-bitter;Picrocrocine;1-Cyclohexene-1-carboxaldehyde,4-(b-D-glucopyranosyloxy)-2,6,6-triMethyl-,(4R)-;Safranbitter;(4S)-2,6,6-trimethyl-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-cyclohexene-1-carbaldehyde |
| CAS号 | 138-55-6 |
| 分子式 | C16H26O7 |
| 分子量 | 330.37 |
| EINECS号 | |
| 相关类别 | 中草药成分;分析试剂标准品;对照品;标准品-对照品;对照品;标准品，对照品;20版药典新增 |
| Mol文件 | 138-55-6.mol |
| 结构式 |  |
苦番紅花素 性质
| 熔点 | 196℃ (ethyl acetate ) |
|---|---|
| 比旋光度 | D20 -58° (c = 0.6) |
| 沸点 | 520.4±50.0 °C(Predicted) |
| 密度 | 1.31±0.1 g/cm3 (20 ºC 760 Torr) |
| 储存条件 | 4°C, protect from light |
| 酸度系数(pKa) | 12.91±0.70(Predicted) |
| LogP | -0.240 (est) |
Picrocrocin，一种发现于椰菜花中的类胡萝卜素。Picrocrocin 具有抗癌作用。Picrocrocin 对 SKMEL-2 人恶性黑色素瘤细胞具有生长抑制作用。
Picrocrocin exerted growth inhibitory effects on the SK-MEL-2 melanoma cells. The IC 50 of picrocrocin against the SK-MEL-2 cells was 20 μM at 24-h incubation. The antiproliferative activity of picrocrocin was due to apoptosis and cell cycle arrest. In addition, picrocrocin enhanced the ROS levels and decreased the MMP levels of SK-MEL-2 cells. Finally, picrocrocin inhibited the JAK/STAT5 signalling pathway in the SK-MEL-2 melanoma cells.