槐黄烷酮 G
| 中文名称 | 槐黄烷酮 G |
|---|---|
| 中文同义词 | 槐黄烷酮 G;苦参新醇;槐属二氢黄酮G;降苦参酮;槐黄烷酮 G、苦参新醇;苦参总黄酮;苦参新醇F/槐黄烷酮G;苦参醇F,降苦参酮,砂生槐黄烷酮G,苦甘草醇 |
| 英文名称 | vexibinol |
| 英文同义词 | vexibinol;(S)-2,3-Dihydro-5,7-dihydroxy-2-(2,4-dihydroxyphenyl)-6-[(R)-5-methyl-2-(1-methylethenyl)-4-hexenyl]-4H-1-benzopyran-4-one;(2S)-5,7-Dihydroxy-2,3-dihydro-2α-(2,4-dihydroxyphenyl)-8-[(R)-5-methyl-2-(1-methylethenyl)-4-hexenyl]-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one,2-(2,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-,(2S)-;Sophoraavanone G;(2S)-2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-8-[(2S)-5-methyl-2-prop-1-en-2-ylhex-4-enyl]-2,3-dihydrochromen-4-one;Sophoraflavanone G,Inhibitor,anti-infammatory,HL60,inhibit,Apoptosis;Hybutimibe Impurity 23 |
| CAS号 | 97938-30-2 |
| 分子式 | C25H28O6 |
| 分子量 | 424.49 |
| EINECS号 | |
| 相关类别 | 植物提取物;标准品;黄酮;新品 |
| Mol文件 | 97938-30-2.mol |
| 结构式 |  |
槐黄烷酮 G 性质
| 熔点 | 173-175℃ |
|---|---|
| 沸点 | 659.3±55.0 °C(Predicted) |
| 密度 | 1.266±0.06 g/cm |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于甲醇； |
| 酸度系数(pKa) | 7.66±0.40(Predicted) |
| 形态 | 粉末 |
| 颜色 | 白黄色 |
| 水溶解性 | sparingly soluble in water |
| 稳定性 | 感光 |
Sophoraflavanone G (Kushenol F) 是从苦参中提取得到的，具有抗肿瘤和抗炎特性。Sophoraflavanone G (Kushenol F) 通过抑制 MAPK 相关途径诱导 MDA-MB-231 和 HL-60 细胞凋亡 (apoptosis)。
IC50: 29.7 μM (MDA-MB-231 cell)
Sophoraflavanone G (0 -100 μM; 24 hours) decreases the viability of the HL-60 cells in a dose-dependent manner. Sophoraflavanone G (0 -100 μM; 24 hours) induces HL-60 cell apoptosis, activated caspase-3 and caspase-9, and downregulated Bcl-2 and Bcl-xL. It also upregulates Bax and released cytochrome c from the mitochondria into the cytoplasm, enabling apoptosis via the mitochondrially-mediated "intrinsic" pathway Sophoraflavanone G (0 -40 μM; 24 hours) inhibits MDA-MB-231 cell viability in a concentration-dependent manner, with an IC 50 value of 29.7 ± 5.2 μM<.br>
化学性质
黄色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂。用途
抗肿瘤、降血糖、抗菌杀虫、抗心律失常。用途
用于含量测定/鉴定/药理实验等