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PF-04620110

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Company Name: career henan chemical co
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Products Intro: Product Name:PF-04620110
CAS:1109276-89-2
Purity:99% Package:1kg;2USD
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Products Intro: Product Name:PF-04620110
CAS:1109276-89-2
Purity:0.98 Package:1kg,2kg,5kg,10kg,25kg
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Products Intro: Product Name:pf-04620110
CAS:1109276-89-2
Purity:0.99 Package:1kg
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226
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Products Intro: Product Name:PF-04620110
CAS:1109276-89-2
Purity:99% Package:10kg 25kg 200 kilograms per barrel Remarks:good
Company Name: Dideu Industries Group Limited
Tel: +86-29-89586680 +86-15129568250
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Products Intro: Product Name:PF-04620110
CAS:1109276-89-2
Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer

PF-04620110 manufacturers

  • PF-04620110
  • PF-04620110 pictures
  • $2.00 / 1kg
  • 2019-07-06
  • CAS:1109276-89-2
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 100kg
PF-04620110 Basic information
Product Name:PF-04620110
Synonyms:Cyclohexaneacetic acid, 4-[4-(4-amino-7,8-dihydro-5-oxopyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl]-, trans-;2-((1r,4r)-4-(4-(4-aMino-5-oxo-7,8-dihydropyriMido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl)cyclohexyl)acetic acid;2-(4-(4-(4-aMiNA-5-oxo-7,8-dihydropyriMido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl)cyclohexyl)acetic acid;2-(trans-4-(4-(4-Amino-5-oxo-7,8-dihydropyrimido[5,4-f]-[1,4]oxazepin-6(5H)-yl)phenyl)cyclohexyl);2-(trans-4-(4-(4-Amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl)cyclohexyl)acetic acid;2-[4-[4-(4-Amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6-yl)phenyl]cyclohexyl]acetic acid;2-(trans-4-(4-(4-Amino-5-oxo-7,8-dihydropyrimido[5,4-f]-[1,4]oxazepin-6(5H)-yl)phenyl)cyclohex;PF-04620110
CAS:1109276-89-2
MF:C21H24N4O4
MW:396.44
EINECS:
Product Categories:Inhibitors
Mol File:1109276-89-2.mol
PF-04620110 Structure
PF-04620110 Chemical Properties
Boiling point 701.9±60.0 °C(Predicted)
density 1.326
storage temp. room temp
solubility DMSO: soluble10mg/mL (clear solution)
pka4.72±0.10(Predicted)
form powder
color white to beige
Safety Information
Hazard Codes Xn
Risk Statements 22
WGK Germany 3
MSDS Information
PF-04620110 Usage And Synthesis
UsesPF 04620110 is an orally-active, inhibitor that has selectivity towards neutral-diglyceride acyltransferase-1 (DGAT-1).
Biological Activitypf-04620110 is a potent, selective and orally-bioavailable inhibitor of diacylglycerol acyltransferase 1 (dgat-1), an enzyme catalyzing the final committed step in the biosynthesis of triglycerides, that inhibits dgat-1 with values of 50% inhibition concentration ic50 of 19 nm and 8 nm in human and ht-29 cells respectively. pf-04620110 displays a highly selective, more than 100 fold, inhibition against dgat-1 rather than a range of lipid processing enzymes, including human dgat-2, human acyl-coa:cholesterol acyltransferase 1, human acyl-coa:wax alcohol acyltransferase 1, human acyl-coa:wax alcohol acyltransferase 2, human acyl-coa:monacylglycerol acyltransferase 2, human acyl-coa:monacylglycerol acyltransferase 3 and mouse mgat 1.lee kr, choi sh, song js, seo h, chae yj, cho he, ahn jh, ahn sh, bae ma. determination of pf-04620110, a novel inhibitor of diacylglycerol acyltransferase-1, in rat plasma using liquid chromatography-tandem mass spectrometry and its application in pharmacokinetic studies. biomed chromatogr. 2013; 27(7):846-852.robert l. dow *, jian-cheng li , michael p. pence , e. michael gibbs , jennifer l. laperle , john litchfield , david w. piotrowski , michael j. munchhof , tara b. manion , william j. zavadoski , gregory s. walker , r. kirk mcpherson , susan tapley , eliot sugarman , angel guzman-perez , and paul dasilva-jardine discovery of pf-04620110, a potent, selective, and orally bioavailable inhibitor of dgat-1. acs med. chem. lett., 2011, 2 (5), pp 407–412
Biochem/physiol ActionsPF-04620110 is known to regulate gut hormones. Inhibition of DGAT1 might serve as a good approach for the treatment of obesity and type 2 diabetes. DGAT1 inhibition might increase the oxidation of fatty acids, thus it is found to be protective against hepatic steatosis.
targetDGAT-1
storageStore at +4°C
PF-04620110 Preparation Products And Raw materials
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