ChemicalBook > Product Catalog >Organic Chemistry >Amides >Acyclic polyamines and their derivatives >Triethylamine

Triethylamine

Triethylamine Suppliers list
Company Name:Thermo Fisher Scientific  Gold
Tel:800-810-5118
Email:cnchemical@thermofisher.com
Company Name:Secco work (Beijing) chemical technology co., LTD  Gold
Tel:010-69755668;
Email:1139670422@qq.com
Company Name:Shanghai Aladdin Bio-Chem Technology Co.,LTD  Gold
Tel:021-20337333/400-620-6333
Email:sale@aladdin-e.com
Company Name:Shanghai Macklin Biochemical Co.,Ltd.  Gold
Tel:021-51821711
Email:sales@macklin.cn
Company Name:Ring Specialty Chemicals Inc.  Gold
Tel:+1 416 493 6870
Email:info@ringchemicals.com
Triethylamine Chemical Properties
mp -115 °C
bp 90 °C
density 0.728
vapor density 3.5 (vs air)
vapor pressure 51.75 mm Hg ( 20 °C)
FEMA 4246
refractive index n20/D 1.401(lit.)
Fp 20 °F
storage temp. 2-8°C
Water Solubility 133 g/L (20 ºC)
Merck 14,9666
BRN 1843166
Stability:Stable. Extremely flammable. Readily forms explosive mixtures with air. Note low flash point. Incompatible with strong oxidizing agents, strong acids, ketones, aldehydes, halogenated hydrocarbons.
CAS DataBase Reference121-44-8(CAS DataBase Reference)
NIST Chemistry ReferenceTriethylamine(121-44-8)
EPA Substance Registry SystemEthanamine, N,N-diethyl-(121-44-8)
Safety Information
Hazard Codes F,C
Risk Statements 11-20/21/22-35
Safety Statements 3-16-26-29-36/37/39-45-61
RIDADR UN 1296 3/PG 2
WGK Germany 1
RTECS YE0175000
34
Hazard Note Highly Flammable/Corrosive
HazardClass 3
PackingGroup II
HS Code 29211910
Hazardous Substances Data121-44-8(Hazardous Substances Data)
MSDS Information
ProviderLanguage
N,N-diethylethanamine English
SigmaAldrich English
ACROS English
ALFA English
Triethylamine Usage And Synthesis
OutlineTriethylamine (formula: C6H15N), also known as N, N- diethylethanamine, is the most simple tri-substituted uniformly tertiary amine, having typical properties of tertiary amines, including salifying, oxidation, Hing Myers test (Hisberg reaction) for triethylamine does not respond. It is colorless to pale yellow transparent liquid, with a strong smell of ammonia, slightly fuming in the air. Boiling point: 89.5 ℃, relative density (water = 1): 0.70, the relative density (Air = 1): 3.48, slightly soluble in water, soluble in alcohol, ether. Aqueous solution is alkaline, flammable. Vapor and air can form explosive mixtures, the explosion limit is 1.2% to 8.0%. It is toxic, with a strong irritant.
Purification and removing waterRemoving water from triethylamine generally uses distillation method. Anhydrous Na2SO4 etc neutral desiccant, or CaCl2 etc alkaline desiccant may be added for drying, and then redistilled.
It is Dried by calcium sulfate, lithium aluminum hydride, 4A molecular sieves, calcium hydroxide, potassium hydroxide or potassium carbonate, and then distilled. Barium oxide and sodium wire may also be used as a desiccant, refluxed with acetic anhydride, benzoic anhydride, phthalic anhydride or toluenesulfonyl chloride, distillate is dried by activated alumina, or solid potassium hydroxide, then distilled to remove trace amounts of a primary amine, a secondary amine contained in triethylamine.
Production methodIt is produced by ethanol and ammonia in the presence of hydrogen, in containing Cu - Ni - clay catalyst reactor under heating conditions (190 ± 2 ℃ and 165 ± 2 ℃) reaction. The reaction also produces ethylamine and diethylamine, products were condensed and then absorption by ethanol spray to obtain crude triethylamine, through the final separation, dehydration and fractionation, pure triethylamine is obtained.
The above information is edited by the chemicalbook of Yan Yanyong.
EffectIt is mainly used as alkali, catalysts, solvents and raw materials in organic synthesis, also used as a high-energy fuel, rubber vulcanization accelerator, tetrafluoroethylene polymerization inhibitors, surfactants, wetting agents, preservatives and fungicides.
Triethylamine at room temperature is the most simple tri-substituted uniformly tertiary amines liquid, and therefore has been widely used as a solvent and the alkali in organic synthesis, usually abbreviated as Et3N, NEt3 or TEA. It is one of the most commonly used in organic synthesis organic alkali. Boiling point is about 89 degrees Celsius, more easily removed by distillation. The solubility of Its hydrochloride and hydrobromide in ether and other organic solvents is not very high, and therefore may be directly Separated by filtration. Simpler trimethylamine was colorless gas under normal conditions, it must be pressurized in storage or in the form of 40% aqueous solution stored in the tank, not easy to be used as triethylamine.
Triethylamine used in elimination reaction, such as Swern oxidation, dehydrohalogenation, etc, Heck reaction, preparation reactions of silyl enol ether, the reaction of preparation of esters and amides by acid chloride, also used as protecting basic catalyst for the hydroxyl, carboxyl and amino. It reacts with hydrochloric acid to produce triethylamine hydrochloride, and reacts with an alkylating agent can produce the corresponding quaternary ammonium salts.
HarmLiquid or vapor can irritate the skin and mucous membranes. After inhalation of vapors, it can make breathing organs, blood circulatory system, central nervous system, liver and other mucosal tissue and other body functions disorder. The maximum allowable concentration at production site is 30mg / m3.
Hazardous characteristics: flammable, vapor and air mixture can form explosive mixtures. For high fever case or the fire, it can cause a fire explosion. It can react strongly with oxidants. Its vapor is heavier than air and can spread to the lower Department of considerable local and met the fire, it will return to burn, it is corrosive.
Chemical PropertiesIt is colorless or pale yellow liquid with a strong smell of ammonia, Soluble in ethanol and ether, Slightly soluble in water.
UsesIt is used for the manufacture of pharmaceuticals, pesticides, polymerization inhibitors, high-energy fuel, rubber vulcanization agent, etc.
It can be used as solvents, catalysts and raw materials in organic synthesis industry. It can be used as catalyst for producing polycarbonate by phosgene, tetrafluoroethylene polymerization inhibitor, rubber vulcanization accelerator, special solvent for paint remover, enamel anti- hardening agents, surface active agents, preservatives, bactericides, ionic exchange resins, dyes, perfumes, pharmaceuticals, high-energy fuel and liquid rocket propellants, etc. The products consuming triethylamine in pharmaceutical industry (consumption of fixed, t / t): ampicillin sodium (0.465), amoxicillin (0.391), Pioneer Ⅳ (2.550), cefazolin sodium (2.442), Cefradine (1.093), piperacillin (0.584), ketoconazole (8.00), vitamin B6 (0.502), enoxacin (10.00), praziquantel (0.667), thiotepa (1.970), penicillamine ( 1.290), berberine (0.030), verapamil (0.540), alprazolam (3.950), o-chloro-phenylacetic acid (0.010) and PPA, etc.
It is used in preparation of fourth amine compounds and synthesis catalyst, also used as solvents, rubber vulcanization accelerator, penetrant and waterproof agent.
Used as a solvent, overcast polymerization inhibitors, preservatives, and synthetic dyes, etc.
It is used for Producing quaternary ammonium compounds, synthesis catalyst, and used as rubber vulcanization accelerator, the solvent for the photographic industry. Mobile phase modifier is used in Reversed-Phase High Performance Liquid Chromatography (RP-HPLC) for separation of acidic, basic and neutral drugs. It can Improve the separation of amino acids and amino acid amide by inhibiting smearing.
CategoryFlammable liquids
Toxicity gradingToxic
Acute toxicityOral - rat LD50: 460 mg / kg; Oral - Mouse LD50: 546 mg / kg
Stimulus dataEyes - rabbit 250 mg severe
Explosive hazardous characteristicsMixed with air can be explosive
Flammability hazard characteristicsIn case of fire, high temperature, oxidant, it is flammable, combustion produces toxic fumes of nitrogen oxides
Chemical PropertiesClear colorless liquid
Storage CharacteristicsTreasury ventilation low-temperature drying, stored separately from oxidants, acids
Extinguishing agentDry, dry sand, carbon dioxide, foam
Occupational standardsTWA 40 mg / cubic meter
General DescriptionA clear colorless liquid with a strong ammonia to fish-like odor. Flash point 20°F. Vapors irritate the eyes and mucous membranes. Less dense (6.1 lb / gal) than water. Vapors heavier than air. Produces toxic oxides of nitrogen when burned.
Air & Water ReactionsHighly flammable. Soluble in water.
Reactivity ProfileTriethylamine reacts violently with oxidizing agents. Reacts with Al and Zn. Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Health HazardVapors irritate nose, throat, and lungs, causing coughing, choking, and difficult breathing. Contact with eyes causes severe burns. Clothing wet with chemical causes skin burns.
Fire HazardFlammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Triethylamine Preparation Products And Raw materials
Raw materialsEtanol-->Ammonia-->Hydrogen-->Diethylamine-->Triethanolamine-->KAOLIN
Preparation Products4-Cyanophenyl isocyanate-->TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD-->ETHYL 2-PHENYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE-->2-CYANO-4-PYRIDINE CARBOXYLIC ACID-->Camostat-->fluorocarbon sulfactant 6201-->Methyl trans-2-nonenoate-->polyurethane water-based emulsion finishes PU-II series-->6-FLUORO-4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINE-->Methyl 2-aminothiophene-3-carboxylate-->DI-2-PYRIDYL THIONOCARBONATE-->2-Thienyl isocyanate-->3-Cyanophenyl isocyanate-->4-(BOC-AMINOMETHYL)PYRIDINE-->5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid-->METHYL 3-[(2-BROMOACETYL)AMINO]THIOPHENE-2-CARBOXYLATE-->2-Chlorophenyl isocyanate-->3-[(N-(TERT-BUTYLOXYCARBONYL)AMINO)METHYL]PYRIDINE-->2-Methoxyphenyl isocyanate-->(R)-Glycidyl butyrate-->4-Fluorophenyl isocyanate-->Triisopropyl phosphite-->N-Boc-N,N-bis(2-chloroethyl)amine-->5-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-3-CARBOXYLIC ACID-->2-FLUOROPHENYL ISOCYANATE-->4-Methoxyphenyl isocyanate-->Metazachlor-->indomethacin farnesil-->2-amino-5-chloro-diphenyl methanol-->S-2-Benzothiazolyl 2-amino-alpha-(methoxyimino)-4-thiazolethiolacetate-->3-FLUOROPHENYL ISOCYANATE-->3,4-(METHYLENEDIOXY)PHENYL ISOCYANATE-->Ampicillin-->1-(4-NITROBENZENESULFONYL)-1H-1,2,4-TRIAZOLE-->3-Hydroxy-6-methyl-2-pyridinemethanol-->Tetraethylammonium bromide-->Pyridat-->N,N-Diethylhydroxylamine-->Dichlormid-->2-Mercaptobenzothiazolyl-(Z)-(2-aminothiazol-4-yl)-2-(tert-butoxycarbonyl) isopropoxyiminoacetate
Tag:Triethylamine(121-44-8) Related Product Information
Ethylenediamine TRIMETHYLAMINE HYDROCHLORIDE 1-(3,4-DIHYDRO-2-NAPHTHYL)PYRROLIDINE Alizarin Fluorine Blue Thymolphthalein Complexone ETHYLENEDIAMINE-N,N'-DIACETIC-N,N'-DIPROPIONIC ACID Triethanolamine Diethylaminoethanol Perfluorotributylamine Triethylamine Diethyltoluenediamine Perfluorotriethylamine DIETHYLALUMINUM CHLORIDE Ethyldiisopropylamine Diethylenetriamine Diethylzinc 2-(2-Aminoethylamino)ethanol N,N-Dimethylethylamine