浅蓝菌素
中文名称 | 浅蓝菌素 |
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中文同义词 | 2,3-环氧-4-氧-7,10-十二碳二烯酰胺;浅蓝菌素;变蓝菌素;天蓝菌素;2,3-环氧-4-氧-7,10-十二碳二烯酰胺/变蓝菌素/天蓝菌素;CERULENIN 浅蓝菌素;铜绿素;CERULENIN 变蓝菌素 |
英文名称 | CERULENIN |
英文同义词 | CERULENIN FROM CEPHALOSPORIUM CAERULENS;[2R-[2.alpha.,3.alpha.(4E,7E)]]-3-(1-Oxo-4,7-nonadienyl)oxiranecarboxamide;2,3-EPOXY-4-OXO-7,10-DODECADIENAMIDE;(2R,3S,E,E)-2,3-EPOXY-4-OXO-7,10-DODECADIENAMIDE;2R,3S-EPOXY-4-OXO-7,10-DODECADIENAMIDE;[2R-[2alpha,3alpha(4E,7E)]]-3-(1-oxonona-4,7-dienyl)oxirane-2-carboxamide;2,3-epoxy-4-oxo-10-dodecadienamide;3-(1-oxo-4,7-nonadienyl)-,(2r-(2-alpha,3-alpha(4e,7e)))-oxiranecarboxamid |
CAS号 | 17397-89-6 |
分子式 | C12H17NO3 |
分子量 | 223.27 |
EINECS号 | 241-424-8 |
相关类别 | 微生物代谢物;抗生素;生化试剂;医药原料;通用生化试剂-抗生素;小分子;antibiotic |
Mol文件 | 17397-89-6.mol |
结构式 |
浅蓝菌素 性质
熔点 | 93.5℃ |
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比旋光度 | D16 +63° (c = 2 in methanol) |
沸点 | bp 120° (10-8 mm) |
密度 | 1.1223 (rough estimate) |
折射率 | 1.5300 (estimate) |
储存条件 | −20°C |
溶解度 | 在丙酮中溶解度:20 mg/mL,澄清,无色至黄色 |
形态 | 白色至类白色固体 |
酸度系数(pKa) | 15.19±0.40(Predicted) |
颜色 | 米白色 |
Merck | 13,2014 |
BRN | 4140423 |
稳定性 | 可在-20°下的DMSO或乙醇溶液保存长达1个月。 |
Fatty acid synthase (FASN)
Cerulenin covalently binds to the catalytic site of FAS and disrupts the condensation reaction of acetyl-COA and malonyl-COA, inhibiting the biosynthesis of fatty acids and sterols in yeast. The Flavonoids quercetin and trans-Chalcone are effective against T. rubrum , with MICs of 125 and 7.5 μg/mL for the wild-type strain (MYA3108) and of 63 and 1.9 μg/mL for the ABC transporter mutant strain (Δ TruMDR2 ), respectively. The MICs of the Fluconazole and Cerulenin controls are 63 and 125 μg/mL for the wild-type strain and 30 and 15 μg/mL for the mutant strain, respectively. To explore the underlying mechanism of Steroidogenic acute regulatory protein (StAR)’s protective effect on endothelial dysfunction model, the inhibitor of fatty acid synthase and HMG-CoA reductase, Cerulenin ( 5 μg/mL) and Lovastatin, are used before palmitic acid (PA) added. The mRNA expression of IL-1β, TNFα, VCAM-1 and IL-6 are reduced while NO production is recovered with inhibitor treatment.
Cerulenin treatment of ob/ob mice has obvious effects on body weight. With 2 days of treatment, body weight in treated mice is decreased compared to a 5.7% weight gain in the controls. With prolonged (7 days) treatment, no body weight loss is observed, but body weight gain is slowed. In all groups, 60 mg/kg of Cerulenin is more effective than 30 mg/kg in inhibiting weight gain. If given daily or every other day, ATP content are increased 58.1% and 61.5% respectively by 7-day treatment of 60 mg/kg Cerulenin. Significant ATP elevation is also observed with only 2 days of treatment with 60 mg/kg Cerulenin. In contrast, 30 mg/kg Cerulenin, given either 2 or 7 days, does not show any significant effect on cellular ATP content.
安全信息
提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/25 | HY-A0210 | Cerulenin | 1 mg | 906元 | |
2024/01/25 | HY-A0210 | 浅蓝菌素 Cerulenin | 17397-89-6 | 5mg | 2380元 |