L-精氨酰-L-赖氨酰-L-ALPHA-谷氨酰-L-缬氨酰-L-酪氨酸二醋酸盐
| 中文名称 | L-精氨酰-L-赖氨酰-L-ALPHA-谷氨酰-L-缬氨酰-L-酪氨酸二醋酸盐 |
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| 中文同义词 | 醋酸脾脏五肽;脾脏五肽;L-精氨酰-L-赖氨酰-L-ALPHA-谷氨酰-L-缬氨酰-L-酪氨酸二醋酸盐;脾胃素二乙酸盐 |
| 英文名称 | ARG-LYS-GLU-VAL-TYR ACETATE SALT |
| 英文同义词 | ARG-LYS-GLU-VAL-TYR ACETATE SALT;SPLENIN FRAGMENT 32-36 ACETATE SALT;SPLENOPENTIN ACETATE SALT;SP-5 ACETATE SALT;ARG-LYS-GLU-VAL-TYR ACETATE;SP-5, Splenin Fragment 32-36, Splenopentin;L-Arginyl-L-lysyl-L-alpha-glutamyl-L-valyl-L-tyrosine diacetate;Splenopentin diacetate |
| CAS号 | 105184-37-0 |
| 分子式 | C33H55N9O11 |
| 分子量 | 753.84 |
| EINECS号 | |
| 相关类别 | 多肽中间体;医药原料药;肽类;peptides pharm |
| Mol文件 | 105184-37-0.mol |
| 结构式 |  |
L-精氨酰-L-赖氨酰-L-ALPHA-谷氨酰-L-缬氨酰-L-酪氨酸二醋酸盐 性质
| 储存条件 | −20°C |
|---|
Splenopentin diacetate 是一种合成的免疫调节性五肽，对应于脾脏激素脾脏蛋白的残基 32-36。Splenopentin diacetate 可影响早期的 T 细胞和 B 细胞分化，从而增加 γ 射线照射后小鼠体内抗体形成细胞的数量。
Splenopentin (1-100 μM) augments human NK cells and has no cytotoxicity.
Splenopentin (0.1 ng/mL-10 μg/mL; 3 h) induces phenotypic differentiation of both T- and B-cell precursor cells.
Splenopentin (1 mg/kg; i.p. three times a week for 7-90 d) accelerates Langerhans cell recruitment and leads to pretreatment levels of Langerhans cell (LC) density in the skin of mice.
Splenopentin (0.01-100 μg per mouse; i.p.) has no demonstrable effect on neuromuscular transmission of mice.
| Animal Model: | Female Balb/c/Bln mice were injected Cyclophosphamide or Dexamethasone for 5 consecutive days |
| Dosage: | 1 mg/kg |
| Administration: | I.p. three times a week for 7-90 days |
| Result: |
Reached the normal number of epidermal LCs at 28 days after the beginning of Cyclophosphamide treatment.
Accelerated restoration process and reached the normal LC density in the skin after 70 days in Dexamethasone treatment grops. |
安全信息
| WGK Germany | 3 |
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| 提供商 | 语言 |
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英文
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