四氢氨基吖啶
| 中文名称 | 四氢氨基吖啶 |
|---|---|
| 中文同义词 | 9-氨基-1,2,3,4-四氢吖啶 盐酸盐;盐酸他克林(四氢氨基吖啶);四氢氨基吖啶;塔克林;9-氨基-1,2,3,4-四氢吖啶盐酸盐水合物;盐酸他克林;盐酸单满吖啶氨;9-氨基-1,2,3,4-四氢吖啶盐酸 |
| 英文名称 | TACRINE HYDROCHLORIDE |
| 英文同义词 | 1,2,3,4-tetrahydro-9-acridinaminmonohydrochloride;1,2,3,4-tetrahydro-9-aminoacridinehydrochloride;1,2,3,4-tetrahydro-9-amino-acridinmonohydrochloride;9-amino-1,2,3,4-tetrahydro-acridinhydrochloride;1,2,3,4-TETRAHYDRO-9-ACRYDINAMINEHCLMONOHYDRATE;1,2,3,4-TETRAHYDRO-9-ACRIDINAMINEHYDROCHLORIDEMONOHYDRATE;1,2,3,4-Tetrahydro-9-Acridinamine Hydrochloride Dihydrate;9-Amino-1,2,3,4-tetrahydroacridine, Hydrochloride Dihydrate |
| CAS号 | 1684-40-8 |
| 分子式 | C13H15ClN2 |
| 分子量 | 234.72 |
| EINECS号 | 216-867-5 |
| 相关类别 | 合成;医药中间体;材料化学;医药;COGNEX;Chemical Amines;Amines;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals;Acetylcholine receptor |
| Mol文件 | 1684-40-8.mol |
| 结构式 |  |
四氢氨基吖啶 性质
| 熔点 | 280-284 °C(lit.) |
|---|---|
| 储存条件 | Inert atmosphere,2-8°C |
| 溶解度 | 溶于水性缓冲液 |
| 酸度系数(pKa) | pKa 9.8 (Uncertain) |
| 形态 | 结晶固体 |
| CAS 数据库 | 1684-40-8(CAS DataBase Reference) |
| EPA化学物质信息 | Tacrine hydrochloride (1684-40-8) |
| Target | Value |
|
BChE
(Cell-free assay) | 25.6 nM |
|
AChE
(Cell-free assay) | 31 nM |
Tacrine (12.5-37.5 nM) inhibits venom acetylcholinesterase as well as human serum butyrylcholinesterase in a concentration-dependent manner.
Tacrine reduces the neurotoxicity induced by the activation of the NMDARs in murine cortical neuronal cultures with an IC
50
of ~500 μM.
Tacrine inhibits the NMDAR responses in a concentration-dependent manner with an IC
50
of ~190 μM at -60 mV.
Tacrine (20-40 μmol/kg; s.c.) disrupts retention of learning in 17- and 30-day old mice in passive avoidance, and while the low dose of tacrine treatment (5 μmol/kg; s.c.) improves retention in 17-day old mice.
Tacrine (0.1-0.4 mg/mL; i.p. for 7 d) inhibits the expression of AChE, but does not significantly improve the protection of the retina function and morphology in mice.
安全信息
| 危险品标志 | T,Xn |
|---|---|
| 危险类别码 | 25-36/37/38-20/22 |
| 安全说明 | 26-36-45 |
| 危险品运输编号 | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS号 | AR9532500 |
| 危险等级 | 6.1(a) |
| 包装类别 | II |
| 毒性 | LD50 intravenous in mouse: 5600ug/kg |