- 2-Methylbenzimidazole
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- $0.00 / 1Kg
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2024-04-08
- CAS:615-15-6
- Min. Order: 1Kg
- Purity: 99.9%
- Supply Ability: 200tons
- 2-Methylbenzimidazole
-
- $100.00 / 1bag
-
2023-09-11
- CAS:615-15-6
- Min. Order: 1bag
- Purity: 99
- Supply Ability: 5000
- 2-Methylbenzimidazole
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- $0.00 / 25KG
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2023-09-08
- CAS:615-15-6
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 50000KG/month
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| | 2-Methylbenzimidazole Basic information |
| | 2-Methylbenzimidazole Chemical Properties |
| Melting point | 175-177 °C (lit.) | | Boiling point | 234.08°C (rough estimate) | | density | 1.1083 (rough estimate) | | refractive index | 1.6013 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Crystalline Powder | | pka | 6.19(at 25℃) | | color | Light beige to brown | | Water Solubility | slightly soluble | | BRN | 112264 | | InChIKey | LDZYRENCLPUXAX-UHFFFAOYSA-N | | CAS DataBase Reference | 615-15-6(CAS DataBase Reference) | | NIST Chemistry Reference | 1H-benzimidazole, 2-methyl-(615-15-6) | | EPA Substance Registry System | 1H-Benzimidazole, 2-methyl- (615-15-6) |
| | 2-Methylbenzimidazole Usage And Synthesis |
| Chemical Properties | light beige to brown crystalline powder. Soluble in alcohol, ether, hot water and sodium hydroxide solution, insoluble in benzene. | | Uses | - 2-Methylbenzimidazole is an important pharmacophore widely used in medicinal chemistry for the synthesis of various antibacterial and antifungal agents.
- It can be used as a key precursor to synthesize substituted benzimidazo[1,2-a]quinolones.
- It can be used in the synthesis of reversible solid-to-liquid phase transition coordination polymer crystals.
- 2-Methylbenzimidazole also exhibits corrosion inhibition.
| | Definition | ChEBI: 2-Methyl-1H-benzo[d]imidazole is a member of benzimidazoles. | | Preparation | 2-Methylbenzimidazole is synthesized by the condensation of o-phenylenediamine with acetic acid. The mixture of o-phenylenediamine and acetic acid is heated at 100°C for 2 hours and then cooled slowly. 10% sodium hydroxide solution is added slowly to the mixture until it is slightly alkaline. The mixture is filtered and washed with cold water. The crude product is then recrystallized with water and decolorized with activated charcoal to obtain the final product. The yield is 68%. | | Synthesis Reference(s) | Journal of Heterocyclic Chemistry, 26, p. 1163, 1989 DOI: 10.1002/jhet.5570260447
Chemical and Pharmaceutical Bulletin, 17, p. 1153, 1969 DOI: 10.1248/cpb.17.1153 | | Safety Profile | Poison by intravenous
route. Moderately toxic by ingestion.
Experimental reproductive effects. Mutation
data reported. When heated to
decomposition it emits toxic fumes of NOx. |
| | 2-Methylbenzimidazole Preparation Products And Raw materials |
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