- Fmoc-L-leu-OH
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- $0.00/ kg
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2024-04-18
- CAS:35661-60-0
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1T
- Fmoc-Leu-OH
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- $0.00 / 25gram
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2023-11-27
- CAS:35661-60-0
- Min. Order: 25gram
- Purity: 99% HPLC
- Supply Ability: 25 gram
- FMOC-L-Leucine
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- $0.00 / 25kg
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2023-07-28
- CAS:35661-60-0
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 1t/month
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| | Fmoc-Leu-OH Basic information |
| | Fmoc-Leu-OH Chemical Properties |
| Melting point | 152-156 °C(lit.) | | alpha | -26 º (c=1,DMF 24 ºC) | | Boiling point | 486.83°C (rough estimate) | | density | 1.2107 (rough estimate) | | refractive index | -25 ° (C=1, DMF) | | storage temp. | Store below +30°C. | | solubility | DMF (Slightly), DMSO (Slightly) | | pka | 3.91±0.21(Predicted) | | form | Solid | | color | White to Off-White | | optical activity | [α]20/D 25±2°, c = 1% in DMF | | BRN | 2178254 | | Stability: | Hygroscopic | | InChIKey | CBPJQFCAFFNICX-IBGZPJMESA-N | | CAS DataBase Reference | 35661-60-0(CAS DataBase Reference) |
| | Fmoc-Leu-OH Usage And Synthesis |
| Description | Fmoc-Leu-OH is isomeric with Fmoc-Ile-OH. Like isoleucine, leucine has branching in the sidechain. The branching is at the gamma carbon instead of the beta carbon as in isoleucine. It is used in chemical and peptide syntheses. | | Chemical Properties | white to light yellow crystal powde | | Uses | Fmoc-L-Leu-OH, is an amino acid derivative, used in peptide chemistry. It is also one of the novel PPARγ ligands that can activate PPARγ in different ways, that reduces osteoclasts differentiation, and thus are better therapeutic targets in diabetes than traditional antidiabetic drugs. | | Application | Fmoc-Leu-OH can be used as a reactant to synthesize:
Various oligopeptides by reacting with functionalized α-amino acid hydrochloride salts.
A cyclic depsipeptide sansalvamide A, a natural product found in marine fungus.
Streptocidin A?D, decapeptide antibiotics naturally found in Streptomyces?sp. Tü 6071.
Coumaroyl dipeptide amide that can be used for cosmetic applications. | | Preparation | Fmoc-L-leucine is prepared by reacting L-leucine with 9-fluorenylmethoxycarbonyl chloride. | | Biological Activity | Anti-inflammatory agent; increases intracellular Ca 2+ levels. PPARγ ligand that induces insulin sensitization, but not adipogenesis. |
| | Fmoc-Leu-OH Preparation Products And Raw materials |
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