5-氨基尿苷
| 中文名称 | 5-氨基尿苷 |
|---|---|
| 中文同义词 | 5-氨基尿苷;化合物 T13511;化合物5-AMINOURIDINE |
| 英文名称 | 5-Aminouridine |
| 英文同义词 | 5-aminouridine;5-AminouridineHClsalt;5-amino-1-(3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl)pyrimidine-2,4-quinone;5-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione;5-azanyl-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione;5-Aminouridine Hcl;Uridine, 5-amino-(6CI,7CI,8CI,9CI);5-Amino-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione |
| CAS号 | 2149-76-0 |
| 分子式 | C9H13N3O6 |
| 分子量 | 259.22 |
| EINECS号 | |
| 相关类别 | 生物化工 |
| Mol文件 | 2149-76-0.mol |
| 结构式 |  |
5-氨基尿苷 性质
| 熔点 | 214-216 °C |
|---|---|
| 密度 | 1.712±0.06 g/cm3(Predicted) |
| 储存条件 | −20°C |
| 酸度系数(pKa) | 9.31±0.10(Predicted) |
| InChI | InChI=1S/C9H13N3O6/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h1,4-6,8,13-15H,2,10H2,(H,11,16,17)/t4-,5-,6-,8-/m1/s1 |
| InChIKey | YBTWWWIJBCCYNR-UAKXSSHOSA-N |
| SMILES | OC[C@H]1O[C@@H](N2C=C(N)C(=O)NC2=O)[C@H](O)[C@@H]1O |
5-Aminouridine 可以修饰核碱基并且可以掺入靶 DNA 中。5-Aminouridine 表现出广泛的生物活性，可抑制肿瘤，真菌和病毒的生长。
This modified nucleobase, 5-Aminouridine, must exhibit a low enough potential to be oxidized by Os(bpy) 3 3+ . These modified nucleobases can be inserted into the target DNA by direct synthesis using modified phosphoramidites.
5-Aminouridine inhibits incorporation of carbamylaspartate into pyrimidines of both RNA and DNA in rat lived and [ 32 P]phosphate into phospholipids and RNA nucleotides of rat liver slices and hepatoma.
安全信息
| WGK Germany | 3 |
|---|