- dermorphin?
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- $90.00 / 10g
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2024-04-19
- CAS:77614-16-5
- Min. Order: 10g
- Purity: 98%
- Supply Ability: 20ton
- dermorphin?
-
- $60.00/ box
-
2024-04-19
- CAS:77614-16-5
- Min. Order: 1box
- Purity: 99%
- Supply Ability: 100000kg
- DERMORPHIN ACETATE
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- $1.00 / 1g
-
2024-04-19
- CAS:77614-16-5
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 100kg
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| | Dermorphin Basic information |
| Product Name: | Dermorphin | | Synonyms: | DERMORPHIN ACETATE;L-Tyr-D-Ala-L-Phe-Gly-L-Tyr-L-Pro-L-Ser-NH2;Tyrosyl-alanyl-phenylalanyl-glycyl-tyrosyl-prolyl-serinamide;Dermorphin trifluoroacetate salt;Dermorphin Powder;(2S)-N-[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carboxamide;Dermorphin HAc;(2S)-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenyl-propanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]-N-[(1S)-1-carbamoyl-2-hydro | | CAS: | 77614-16-5 | | MF: | C40H50N8O10 | | MW: | 802.87 | | EINECS: | 202-853-6 | | Product Categories: | 77614-16-5 | | Mol File: | 77614-16-5.mol |  |
| | Dermorphin Chemical Properties |
| Melting point | 157-159 °C | | Boiling point | 1323.8±65.0 °C(Predicted) | | density | 1.363±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO | | form | powder | | pka | 9.83±0.15(Predicted) | | color | white to off-white | | Sequence | H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2 | | InChIKey | FHZPGIUBXYVUOY-VWGYHWLBSA-N | | SMILES | C(N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N)(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](C)NC(=O)[C@@H](N)CC1C=CC(O)=CC=1)CC1C=CC=CC=1)CC1C=CC(O)=CC=1 |
| | Dermorphin Usage And Synthesis |
| Description | Dermorphin was first isolated from the skin of the skin of South American frogs of the genus Phyllomedusa. It is a high potency natural opiate peptide that binds selectively to mu-opioid receptors. | | Uses | A mu-opioid receptor agonist | | Definition | ChEBI: Dermorphin is an oligopeptide. | | Side effects |
Like μ-opiate agonists, dermorphins produce antinociception and also catalepsy, respiratory depression, constipation, tolerance, and dependence, although at a lower degree than morphine does[1].
| | in vitro | Dermorphin, a peptide isolated from the skin of Phyllomedusa frogs and the peptide receptor (NOP) component by the endogenous agonist nociceptin/orphanin FQ (N/OFQ). In displacement binding studies at CHOhMu, Dermorphin and DeNo displac the binding of [3H]-DPN in a concentration dependent and saturable manner. Dermorphin displays an affinity of 7.17, while N/OFQ fails to displace [3H]-DPN at the Delta receptor. Dermorphin and DeNo stimulate the binding of GTPγ[35S] in a concentration dependent and saturable manner at the Mu receptor.
| | References | [1] Negri, L. P. Melchiorri and R. Lattanzi. “Opioid and Bv8 Peptides.”Handbook of Biologically Active Peptides (Second Edition) 2013:376-383.
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| | Dermorphin Preparation Products And Raw materials |
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