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Clomifene

Clomifene Suppliers list
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Products Intro: Product Name:Clomifene
CAS:911-45-5
Purity:99.9% Package:>=1bottle;15USD/bottle|>=10bottle;12USD/bottle|>=20bottle;8USD/bottle
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Products Intro: Product Name:911-45-5 Clomifene
CAS:911-45-5
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CAS:911-45-5
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Products Intro: Product Name:Clomiphene
Purity:98% Package:1kg;25kg
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Products Intro: Product Name:clomifene
CAS:911-45-5
Purity:99% Package:1kg

Clomifene manufacturers

  • Clomiphene
  • Clomiphene pictures
  • $15.00 / 1bottle
  • 2024-03-28
  • CAS:911-45-5
  • Min. Order: 1bottle
  • Purity: 99.9%
  • Supply Ability: 1000 ton
  • Clomifene
  • Clomifene pictures
  • $15.00/ bottle
  • 2024-01-20
  • CAS:911-45-5
  • Min. Order: 1bottle
  • Purity: 99.9%
  • Supply Ability: 200tons/year
  • Clomifene
  • Clomifene pictures
  • $200.00 / 10g
  • 2022-11-22
  • CAS:911-45-5
  • Min. Order: 10g
  • Purity: 99%
  • Supply Ability: 1000t/month

Related articles

  • Hormonal modulation:CLOMIPHENE
  • Clomiphene is an antiestrogen thought to increase sperm parameters in males attempting to conceive. The objective of this revi....
  • Dec 22,2021
Clomifene Basic information
Description Hormonal modulation
Product Name:Clomifene
Synonyms:clomifene;Clomiphene;Clomiphene,E/Z-mixture;2-(4-[2-Chloro-1,2-diphenylethenyl]phenoxy)-N,N-diethylethanamine;CLOMIFENE (CLOMIPHENE);2-[4-(2-Chloro-1,2-diphenylvinyl)phenoxy]-N,N-diethylethan-1-amine;2-[4-(2-Chloro-1,2-diphenylvinyl)phenoxy]-N,N-diethylethanamine;Clomiphene B
CAS:911-45-5
MF:C26H28ClNO
MW:405.96
EINECS:213-008-6
Product Categories:
Mol File:911-45-5.mol
Clomifene Structure
Clomifene Chemical Properties
Melting point 117.25°C
Boiling point 509.0±50.0 °C(Predicted)
density 1.0166 (rough estimate)
refractive index 1.5790 (estimate)
storage temp. Amber Vial, -20°C Freezer
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form Solid
pka9.54±0.25(Predicted)
color White to Pale Yellow
InChIInChI=1S/C26H28ClNO/c1-3-28(4-2)19-20-29-24-17-15-22(16-18-24)25(21-11-7-5-8-12-21)26(27)23-13-9-6-10-14-23/h5-18H,3-4,19-20H2,1-2H3
InChIKeyGKIRPKYJQBWNGO-UHFFFAOYSA-N
SMILESC(N(CC)CC)COC1=CC=C(C(C2=CC=CC=C2)=C(Cl)C2=CC=CC=C2)C=C1
NIST Chemistry ReferenceClomiphene(911-45-5)
EPA Substance Registry SystemClomiphene (911-45-5)
Safety Information
Hazardous Substances Data911-45-5(Hazardous Substances Data)
MSDS Information
Clomifene Usage And Synthesis
DescriptionClomiphene is an antiestrogen thought to increase sperm parameters in males attempting to conceive. The objective of this review was to evaluate the efficacy and safety of Clomiphene citrate in the treatment of male patients with infertility. It is an oral agent used to treat infertility in women desiring pregnancy. Clomiphene has been linked to a low rate of transient serum aminotransferase elevations during therapy and to rare instances of clinically apparent liver injury, which can be severe and even fatal.A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue.
Hormonal modulationCLOMIPHENE exerts its effects centrally with a result of increased LH and FSH secretion and increased testicular testosterone production. Many studies have described significant increases in serum testosterone, LH, and FSH with CLOMIPHENE treatment. Studies have revealed comparable increases in serum testosterone levels in hypogonadal men treated with CLOMIPHENE compared with TRT. CLOMIPHENE has also been compared with aromatase inhibitors, such as anastrozole, and CLOMIPHENE has proven to be more effective in increasing testosterone levels.
OriginatorClomid,Lepetit,Italy,1966
UsesClomifene is used for infertility in order to increase reproductive properties of oligoovulatory women who have three or four ovulatory cycles per year, leading to normal monthly ovulation.
UsesAntiestrogen.
IndicationsClomifene acts by enhancing follicular growth caused by ovulation. The primary indication for using clomifene is induction of ovulation in non-ovulating women who still have some estrogen production.
DefinitionChEBI: Zuclomifene is a stilbenoid.
Manufacturing ProcessA mixture of 20 g of 1-[p-(β-diethylaminoethoxy)phenyl]-1,2-diphenylethanol in 200 cc of ethanol containing an excess of hydrogen chloride was refluxed 3 hours. The solvent and excess hydrogen chloride were removed under vacuum, and the residue was dissolved in a mixture of ethyl acetate and methylene chloride. 1-[p-(β-diethylaminoethoxy)phenyl]-1,2-diphenylethylene hydrochloride was obtained, melting at 148° to 157°C. This hydrochloride salt was treated with N-chlorosuccinimide in dry chloroform under reflux. The product then obtained was converted to the free base and treated with citric acid. The dihydrogen citrate salt of 1-[p-(β-diethylaminoethoxy)phenyl]-1,2- diphenylchloroethylene was obtained, melting at 116.5° to 118°C.
The intermediate 1-[p-(β-diethylaminoethoxy)phenyl]-1,2-diphenylethanol was obtained by treating 4-(β-diethylaminoethoxy)benzophenone with benzylmagnesium chloride. It melted at 95° to 96°C.
Brand nameClomid (Sanofi Aventis); Serophene (Serono).
Therapeutic FunctionAntiestrogen
SynthesisClomifene, 2-[p-(2-chloro-1,2-diphenylvinyl)phenoxy]triethylamine (28.2.4), is synthesized from 4-hydroxybenzophenone by reacting it with 2-diethylaminoethylchloride in the presence of an alkali, which gives 4-(2-diethylaminoethoxy)benzophenone (28.2.1). This is reacted with benzylmagnesium chloride in a Grignard reaction, forming as a result the corresponding carbinol (28.2.2). Dehydrating this with hydrogen chloride gives 2-[p-(1,2-diphenylvinyl) phenoxy]triethylamine (28.2.4), the vinylic hydrogen atom of which is replaced with a chlorine atom using N-chlorosuccinimide, giving clomifene (28.2.4) .

Synthesis_911-45-5

Tag:Clomifene(911-45-5) Related Product Information
Chlorodiphenylphosphine Dichlorodiphenylsilane Diphenyldimethoxysilane p-(2-Methoxyethyl) phenol Methoxydiethylborane 1,5-Diphenylcarbazide 2-(2-Aminoethylamino)ethanol 3,4'-DIAMINODIPHENYLMETHANE Epichlorohydrin Difluorochloromethane Clomiphene Citrate Enclomiphene Chloroacetic acid CIS-CLOMIPHENE HCL,cis-clomiphen 2-[5-(4-Chlorophenyl)pentyl]oxirane-2-carboxylic acid CLOMIFENE CITRATE FOR PERFORMANCE TEST Clomifene CLOMIPHENE RELATED COMPOUND A (100 MG) ((E,Z)-2-[4-(1,2-DIPHENYLETHENYL)PHENOXY]-N,N- DIETHYLETHANAMINE HYDROCHLORIDE)