化合物 T32535
| 中文名称 | 化合物 T32535 |
|---|---|
| 中文同义词 | |
| 英文名称 | LADOSTIGIL |
| 英文同义词 | LADOSTIGIL;Ladostigil (TV-3,326);LHXOCOHMBFOVJS-OAHLLOKOSA-N;Carbamic acid, N-ethyl-N-methyl-, (3R)-2,3-dihydro-3-(2-propyn-1-ylamino)-1H-inden-5-yl ester |
| CAS号 | 209394-27-4 |
| 分子式 | C16H20N2O2 |
| 分子量 | 272.34 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 209394-27-4.mol |
| 结构式 |  |
化合物 T32535 性质
| 沸点 | 412.4±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.14±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 6.94±0.20(Predicted) |
|
MAO-B 37.1 μM (IC 50 ) |
AChE 31.8 μM (IC 50 ) |
Ladostigil (1-10 µM) exerts neuroprotective activities, including a prevention of the fall of the mitochondrial membrane potential (ψ), attenuation of apoptotic cascades and an inhibition of ROS production induced by OS insults.
Ladostigil (1-10 µM) has a significant neuroprotective activity, including inhibition of caspase-3 activation, induction of Bcl-2 and reduction of Bad and Bax gene and protein expression in human neuroblastoma SK-N-SH cells.
Ladostigil (17 mg/kg; p.o. daily for 6 weeks) abolishes their hyperanxiety and depressive-like behaviour in the elevated plus maze (EPM) and forced swim tests (FST) tests in adulthood from puberty to prenatally-stressed rats.
Ladostigil (50 μmol/kg; single p.o.) restores the loss of episodic memory in the object recognition test in rats.
| Animal Model: | Pathogen-free (SPF) Sprague-Dawley rats |
| Dosage: | 17 mg/kg |
| Administration: | P.o. (added to the drinking water) daily for 6 weeks |
| Result: |
Inhibited brain MAO-A and B by more than 60%.
Reduced hyperanxiety of male and female prenatally stressed (PS) rats in the EPM and depressive-like behaviour in the FST. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-10399 | Ladostigil | 209394-27-4 | 5mg | 4500元 |
| 2024/01/25 | HY-10399 | Ladostigil | 1 mg | 2045元 |