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Phenacetin

Phenacetin Suppliers list
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Products Intro: Product Name:Phenacetin
CAS:62-44-2
Purity:99% Package:90/KG
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Products Intro: Product Name:Phenacetin
CAS:62-44-2
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Products Intro:Product Name:Phenacetin
CAS:62-44-2
Purity:99% HPLC Package:25g,100g,500g
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Products Intro:CAS:62-44-2
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Products Intro:Product Name:Phenacetin
CAS:62-44-2
Purity:99.5% Package:1kg25kg
Phenacetin Basic information
Indications and Usage Mechanisms of Action Side Effects Category Acute toxicity Inflammability and Hazardous Property Storage Characteristics Extinguishing agent
Product Name:Phenacetin
Synonyms:1-ACETYL-P-PHENETIDIN;4-ACETOPHENETIDIDE;4-acetophenetidine;4'-ETHOXYACETANILIDE;4-ETHOXYACETANILIDE;ACETOPHENETIDIN;ACETOPHENETIDINE;ACET-P-PHENETIDINE
CAS:62-44-2
MF:C10H13NO2
MW:179.22
EINECS:200-533-0
Product Categories:Other APIs;Organics;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:62-44-2.mol
Phenacetin Structure
Phenacetin Chemical Properties
Melting point 133-136 °C(lit.)
Boiling point 132 °C / 4mmHg
Fp 2℃
storage temp. 2-8°C
form powder
color White
Water Solubility 0.076 g/100 mL
Sensitive Hygroscopic
Merck 14,7204
BRN 1869238
Stability:Stable. Incompatible with strong oxidizing agents, strong acids.
InChIKeyCPJSUEIXXCENMM-UHFFFAOYSA-N
CAS DataBase Reference62-44-2(CAS DataBase Reference)
NIST Chemistry ReferenceAcetamide, N-(4-ethoxyphenyl)-(62-44-2)
EPA Substance Registry SystemAcetamide, N-(4-ethoxyphenyl)-(62-44-2)
Safety Information
Hazard Codes T,F
Risk Statements 45-22-20/21/22-36-11
Safety Statements 53-45-36/37-26-16
RIDADR UN 3077 9 / PGIII
WGK Germany 3
RTECS AM4375000
TSCA Yes
Hazardous Substances Data62-44-2(Hazardous Substances Data)
MSDS Information
ProviderLanguage
4-Acetophenetidine English
ACROS English
SigmaAldrich English
ALFA English
Phenacetin Usage And Synthesis
Indications and UsagePhenacetin is mainly used as an antipyretic analgesic, with slow and lasting effects, treating headaches, neuralgia, joint pain, and fever, and weakly resisting rheumatism and inflammation. Because of toxic side effects and the rapid development of similar drugs, however, it is no longer used alone, only as a raw material in combination with other drugs. Commonly combined with aspirin and caffeine to form a less toxic compound aspirin used to treat the common cold. Can make chlorpheniramine cold tablets by adding a small amount of chlorpheniramine to the above compound, used to treat colds with headache, neuralgia, rheumatism, etc. Can be used as a material for organic synthesis or a pharmaceutical intermediate.
Mechanisms of ActionOn its own, phenacetin has no antipyretic or analgesic effects. In vivo, acetaminophen and paracetamol are metabolized and decomposed to create the antipyretic and analgesic effects. Its decomposites with ammonia and phenyl either not only have no antipyretic and analgesic effects, but also are major factors in its side effects.
Side EffectsLong term use may cause renal papillary necrosis and interstitial nephritis, and even induce renal pelvic cancer and bladder cancer. Phenacetin also makes the hemoglobin to form methemoglobin, decreasing blood oxygen carrying capacity, causing cyanosis. In addition, Phenacetin can cause hemolysis and hemolytic anemia, and is toxic to the retina. Long term use may cause also lead to dependence. Countries including America, Britain, German, and Japan have banned Phenacetin, or required packaging to note that it is “not indicated for long-term usage or large doses.”
CategoryToxic Substance
Acute toxicityOral administration – rats: LD50: 3600 mg/kg; oral administration - mice LD50: 866 mg/kg
Inflammability and Hazardous PropertyCombustible on open flame; decomposes and releases toxic nitrous oxide gas when heated; side effects: pale color, liver damage, hemoglobin disease.
Storage CharacteristicsStore in ventilated, cool, and dry conditions, separate from reducing agents and food additives.
Extinguishing agentMist, foam, carbon dioxide, sand.
Chemical Propertieswhite crystalline powder
UsesAnalgesic, antipyretic. Component of APC tablets, analgesic mixture also containing aspirin and caffeine. Phenacetin is reasonably anticipated to be a human carcinogen; analgesic mixtures containing Phenacetin are listed as known human carcinogens.
Usesglycosylation inhibitor
DefinitionChEBI: A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen is substituted by a 4-ethoxyphenyl group.
General DescriptionOdorless fine white crystalline solid with a lightly bitter taste. Used as an analgesic medicine.
Air & Water ReactionsInsoluble in water.
Reactivity ProfilePhenacetin react with oxidizing agents, iodine and nitrating agents.
Fire HazardFlash point data for Phenacetin are not available but Phenacetin is probably combustible.
Phenacetin Preparation Products And Raw materials
Preparation Products4-ETHOXY-N-METHYLACETANILIDE
Raw materialsAcetic acid glacial-->Acetic anhydride-->4-Acetamidophenol-->Iodoethane-->Phenetidine-->phenylacetic anhydride
Tag:Phenacetin(62-44-2) Related Product Information
2-HYDROXYBENZOIC ACID 4-(ACETYLAMINO)PHENYL ESTER N-(4-ETHOXYPHENYL)MALEAMIC ACID N-LACTOYL-P-PHENETIDINE N-(4-ethoxy-3-nitrophenyl)acetamide Acetoacet-p-phenetidide 4-CHLORO-N-(4-ETHOXYPHENYL)BENZAMIDE Phenacetin Phenetole Sulfanilic acid 4-Aminophenylacetic acid 4-Amino-benzenesulfonic acid monosodium salt 4-Dimethylaminobenzoic acid P-AMINOBENZAMIDE GLUTAMIC ACID Benzocaine o-Phenetidine p-Anisidine Sulfanilamide 4-Aminobenzoic acid