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| | cis-4-Hydroxy-L-proline Basic information |
| | cis-4-Hydroxy-L-proline Chemical Properties |
| Melting point | 257 °C (dec.) (lit.) | | alpha | -59 º (c=2, H2O) | | Boiling point | 242.42°C (rough estimate) | | density | 1.3121 (rough estimate) | | refractive index | -59 ° (C=2, H2O) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | soluble | | form | Powder | | pka | 2.14±0.40(Predicted) | | color | White to beige | | Water Solubility | soluble | | Merck | 14,4840 | | BRN | 81440 | | InChIKey | PMMYEEVYMWASQN-IMJSIDKUSA-N | | CAS DataBase Reference | 618-27-9(CAS DataBase Reference) | | EPA Substance Registry System | L-Proline, 4-hydroxy-, (4S)- (618-27-9) |
| | cis-4-Hydroxy-L-proline Usage And Synthesis |
| Chemical Properties | White to beige powder | | Uses | cis-4-Hydroxy-L-proline (CHP) is a proline analog that inhibits collagen synthesis and has been used as an anticancer compound. CHP blocked myotube formation and expression of sarcomeric myosin heavy chain in C2C12 murine skeletal muscle cells. CHP inhibited proliferation of murine Panc02 pancreatic carcinoma cell line and rat pancreatic carcinoma cell line DSL6A. | | Uses | cis-4-Hydroxy-L-proline (CHP) is a proline analog that inhibits collagen synthesis and has been used as an anticancer compound. CHP blocked myotube formation and expression of sarcomeric myosin heavy chain in C2C12 murine skeletal muscle cells. CHP inhibited proliferation of murine Panc02 pancreatic carcinoma cell line3 and rat pancreatic carcinoma cell line DSL6A. cis-4-Hydroxy-L-proline and other hydrosyl-L-prolines are important intermediates for chiral synthesis of potential drugs. | | Uses | Hydroxyprolines are valuable chiral building blocks for organic synthesis of pharmaceuticals. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline. | | Definition | ChEBI: L-Proline in which a hydrogen at the 4-position of the pyrrolidine ring is substituted by a hydroxy group (S-configuration). | | Biochem/physiol Actions | cis-4-Hydroxy-L-proline (CHP) and its derivatives may have anticancer activity. cis-4-Hydroxy-L-proline and other hydrosyl-L-prolines are important intermediates for chiral synthesis of potential drugs. |
| | cis-4-Hydroxy-L-proline Preparation Products And Raw materials |
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