2-吲哚酮
| 中文名称 | 2-吲哚酮 |
|---|---|
| 中文同义词 | 2-吲哚酮;氧化吲哚;羟吲哚;2-吲哚酮(2-羟基吲哚);1,3-二氢-吲哚-2-酮;鄰胺苯乙酸內醯胺;2-羥吲哚;吲哚二酮 |
| 英文名称 | Oxindole |
| 英文同义词 | OXINDOL;OXINDOLE;O-(AMINOPHENYL)ACETIC ACID LACTAM;TIMTEC-BB SBB004215;2-Oxo-2,3-dihydroindole;NSC 274863;1,3-dihydro-2h-indol-2-on;1,3-Dihydroindol-2-one |
| CAS号 | 59-48-3 |
| 分子式 | C8H7NO |
| 分子量 | 133.15 |
| EINECS号 | 200-429-5 |
| 相关类别 | 吲哚类;硼酸系列;吲哚;细胞生物学;苯基硼酸类及衍生物系列;医药中间体;有机原料-酮;分析试剂标准品;生物碱;杂环化合物;有机化工原料;化工中间体;杂质对照品;化工原料;其他原料;blocks;IndolesOxindoles;Aromatic Phenylacetic Acids and Derivatives;Indoles and derivatives;Indoline & Oxindole;Indoles;Indole Derivatives;Heterocycle-Indole series |
| Mol文件 | 59-48-3.mol |
| 结构式 |  |
2-吲哚酮 性质
| 熔点 | 123-128 °C(lit.) |
|---|---|
| 沸点 | 227 °C73 mm Hg(lit.) |
| 密度 | 1.1475 (rough estimate) |
| 折射率 | 1.5282 (estimate) |
| 闪点 | 194-196°C/17mm |
| 储存条件 | Sealed in dry,Room Temperature |
| 溶解度 | 9.1g/l |
| 形态 | 固体 |
| 酸度系数(pKa) | 14.77±0.20(Predicted) |
| 颜色 | 浅棕色 |
| 水溶解性 | insoluble |
| BRN | 114692 |
| CAS 数据库 | 59-48-3(CAS DataBase Reference) |
| NIST化学物质信息 | 2H-Indol-2-one, 1,3-dihydro-(59-48-3) |
| EPA化学物质信息 | Oxindol (59-48-3) |
Oxindole (Indolin-2-one) is a bicyclic structure consisting of a benzene ring fused to 2-pyrrolidone. Substituted indolinones can be referred as ‘privileged structures’ owing to their excellent binding affinity for many receptors and to the number of approved drugs containing this scaffold. Oxindole has been found in tissues and fluids of mammals as well as natural products produced by a range of plants, bacteria and invertebrates. 2-indolinone derivatives possess diverse range of pharmacological activities including anti-cancer, anti-HIV, anti-diabetic, antibacterial, antioxidant, kinase inhibitory, AChE inhibitory, anti-leishmanial, b3 adrenergic receptor agonistic, phosphatase inhibitory, analgesic, spermicidal, vasopressin antagonists, progesterone antagonists, neuroprotection, NMDA blocker and sleep inducing activities.
吲哚类似物； 显示药理活性。
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