- 4-Hydroxycinnamic acid
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- $0.00 / 25Kg/Drum
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2024-04-25
- CAS:501-98-4
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 500mt/year
- 4-Hydroxycinnamic acid
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- $0.00 / 1kg
-
2024-04-25
- CAS:501-98-4
- Min. Order: 1kg
- Purity: 99%+
- Supply Ability: 1000000kg per Month
- p-Coumaric acid
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- $8.00 / 20Grams
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2024-04-24
- CAS:501-98-4
- Min. Order: 20Grams
- Purity: 99.99%
- Supply Ability: 100Tons
Related articles - What is p-Coumaric acid used for?
- p-coumaric acid, a phytochemical and nutraceutical, can be found in several edible plants like tomatoes, carrots, and cereals.....
- May 23，2023
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| | p-Coumaric acid Basic information |
| | p-Coumaric acid Chemical Properties |
| Melting point | 214 °C (dec.)(lit.) | | Boiling point | 231.61°C (rough estimate) | | density | 1.1403 (rough estimate) | | refractive index | 1.4500 (estimate) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | ethanol: soluble50mg/mL | | form | Powder | | pka | 4.65±0.10(Predicted) | | color | Off-white to beige or greenish | | Odor | at 100.00?%. balsamic | | Water Solubility | soluble | | Merck | 14,2560 | | BRN | 2207383 | | Stability: | Light Sensitive | | InChIKey | NGSWKAQJJWESNS-ZZXKWVIFSA-N | | LogP | 1.460 | | CAS DataBase Reference | 501-98-4(CAS DataBase Reference) | | NIST Chemistry Reference | p-Hydroxycinnamic acid(501-98-4) | | EPA Substance Registry System | 2-Propenoic acid, 3-(4-hydroxyphenyl)-, (2E)- (501-98-4) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-37/39 | | WGK Germany | 2 | | RTECS | GD9095000 | | HS Code | 29163990 |
| | p-Coumaric acid Usage And Synthesis |
| Chemical Properties | Off-white to beige or greenish powder. Soluble in alcohol, ether and hot water, slightly soluble in benzene, insoluble in petroleum ether. | | Uses | trans-p-Coumaric Acid is the E-isomer of p-Coumaric Acid (C755365), a hydroxy derivative of Cinnamic Acid with antioxidant properties. p-Coumaric acid is a is a major component of lignocellulose. Stud
ies suggest that p-Coumaric Acid may reduce the risk of cancer by reducing the formation of carcinogenic nitrosamines. | | Definition | ChEBI: p-coumaric acid is the trans-isomer of 4-coumaric acid. 4-coumaric acid is a coumaric acid in which the hydroxy substituent is located at C-4 of the phenyl ring. It has a role as a plant metabolite. It is a conjugate acid of a 4-coumarate. | | Preparation | Synthesis of p-Coumaric acid: take o-acetylsalicyloyl chloride as raw material, in the presence of magnesium chloride, react with diethyl malonate in acetonitrile solvent, then add triethylamine, and react at 0°C for 1 h to obtain ( 2-acetoxybenzoyl) diethyl malonate product, then heated to 50°C in potassium hydroxide/methanol solution, reacted for 3h, and cyclized to obtain p-Coumaric acid. | | Application | trans-4-Hydroxycinnamic acid is used as a hydroxycinnamic acid with antioxidant properties. p-Coumaric acid is an aromatic phytochemical for proteomics research. It has been used as a component of chemiluminescent substrate for protein detection in western blotting. | | Biochem/physiol Actions | p-Coumaric acid is mainly a plant metabolite which exhibits antioxidant and anti-inflammatory properties. It also shows bactericidal activity by damaging bacterial cell membrane and by interacting with bacterial DNA. In western blot, p-coumaric is also used as an enhancer in chemiluminescent substrate.
Hydroxycinnamic acid found in many fruits and vegetables. | | Purification Methods | Crystallise p-coumaric acid from H2O (charcoal). It forms needles from concentrated aqueous solutions as the anhydrous acid, but from hot dilute solutions the monohydrate acid separates on slow cooling. The acid (33g) has been crystallised from 2.5L of H2O (1.5g charcoal) yielding 28.4g of recrystallised acid, m 207o. It is insoluble in *C6H6 or pet ether. The UV in 95% EtOH has max 223 and 286nm ( 14,450 and 19000 M-1cm-1). [UV Wheeler & Covarrubias J Org Chem 28 2015 1963, Corti Helv Chim Acta 32 681 1949, Beilstein 10 IV 1005.] |
| | p-Coumaric acid Preparation Products And Raw materials |
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