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Tigecycline

Tigecycline Suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: +86 (0)571-855 867 18
Email: sales@capotchem.com
Products Intro: Product Name:Tigecycline
CAS:220620-09-7
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Nanjing Gold Pharmaceutical Technology Co. Ltd.
Tel: 025-84209270 15906146951
Email: wgp@nanjing-pharmaceutical.com
Products Intro: Product Name:Tigecycline
CAS:220620-09-7
Purity:99% Package:50KG;25KG;10KG;5KG;1KG
Company Name: Dalian Meilun Biotech Co., Ltd.  Gold
Tel:0411-66771943;0411-66771942
Email:sales@meilune.com
Products Intro:Product Name:Tigecycline
CAS:220620-09-7
Purity:>99.0% Package:680RMB/500MG Remarks:Meilunbio
Company Name: Beijing Hope International Pharmaceutical Technology Development Co., Ltd  Gold
Tel:010-67886402
Email:liping@hopelife.cn
Products Intro:Product Name:Tigecycline
CAS:220620-09-7
Company Name: Wuhan Biocar Bio-Pharm Co., Ltd.  Gold
Tel:17764003753
Email:sales@biocar.cn
Products Intro:Product Name:Tigecycline
CAS:220620-09-7
Purity:99% HPLC Package:25kg;5KG;1KG
Tigecycline Basic information
Indications and Usage Mechanisms of Action Adverse reaction
Product Name:Tigecycline
Synonyms:2-NAPHTHACENECARBOXAMIDE, 4,7-BIS(DIMETHYLAMINO)-9-[[[(1,1-DIMETHYLETHYL)AMINO]ACETYL]AMINO]-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-, (4S,4AS,5AR,12AS)-;(4s,4as,5ar,12as)-4,7-bis(dimethylamino)-9-[(tert-butylamino)acetamido]-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracen-2-carboxamide;tigecycline;TIGECYCLINE GLYCYLCYCLINE;(4S,4As,5aR,12as)-4,7-Bis(dimethylamino)-9-{(tert-butylamino)acetamido}-3,10,12,12a-octahydrotetracen-2-carboxamide;(4S,4aS,5aR,12aS)-4,7-Bis(dimethylamino)-9-[(tert-butylamino)acetamido]-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracen-2-carboxamide;2-NAPHTHACENECARBOXAMIDE;TIGECYCLINE POWDER
CAS:220620-09-7
MF:C29H39N5O8
MW:585.65
EINECS:
Product Categories:Antibacterial;API;Amines;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:220620-09-7.mol
Tigecycline Structure
Tigecycline Chemical Properties
Melting point 164-166°C
storage temp. Amber Vial, -20°C Freezer
CAS DataBase Reference220620-09-7(CAS DataBase Reference)
Safety Information
Safety Statements 24/25
RIDADR 3077
MSDS Information
Tigecycline Usage And Synthesis
Indications and UsageTigecycline is also called 9-tert-glycylaminomycetine or diclofenac, and it is a new type of venous injection antibiotic with broad-spectrum activities. It is a type of 9-tert-glycylaminomycetine derivative and is the first glycylcine antibiotic.
Tigecycline can serve as a second option after failed first-line treatment for multi-drug resistant bacteria, and it is also a new treatment option for patients who are allergic to penicillin or intolerable to other drugs. It can treat patients 18 years old or above with complex skin and skin structure infections or complex abdominal infections such as complex appendicitis, burn infections, abdominal abscesses, deep soft tissue infections, and ulcer infections.
Mechanisms of ActionTigecycline’s mechanisms of action are similar to those of tetracycline antibiotics, which are binding with bacterial 30S ribosomes to prevent transfer RNA from entering, making it impossible for amino acids to form peptide chains, thus preventing bacterial protein synthesis and limiting bacterial growth. However, tigecycline’s ability to bind with ribosomes is 5 times that of other tetracycline antibiotics, which means that tetracycline’s anti-drug resistance ability is stronger. Tigecycline’s structure is similar to that of minocycline, but tigecycline’s antibacterial activity is much stronger, and bacteria are less likely to develop resistance to it compared to other tetracycline drugs, and it can also act on the methicillin-resistant Staphylococcus aureus. Tigecycline’s antifungal spectrum includes gram-positive bacteria, gram-negative bacteria and anaerobic bacteria. In vitro experiments and clinical trials showed that tigecycline is sensitive to some aerobic gram-negative bacteria (such as Citrobacter freundii, Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae and Klebsiella pneumoniae, Acinetobacter baumannii, Aeromonas hydrophila, Citrobacter Enterobacteriaceae, hemorrhagic Pasteurella, Serratia marcescens, and Stenotrophomonas maltophilia). Pseudomonas auruginosa is resistant to tigecycline.
Adverse reactionThe most common adverse effects are nausea and vomiting, which usually happens in the first 1-2 days of treatment and are mild to moderate in intensity. In a positive drug control clinical trial, 35% percent of complex skin and skin structure infection patients using tigecycline experienced nausea, and 20% experienced vomiting; vancomycin/aztreonam use caused 8.9% nausea and 4.2% vomiting. 25.3% of complex abdominal infection patients using tigecycline experienced nausea, and 19.5% experienced vomiting; vancomycin/aztreonam caused 20.5% nausea and 15.3% vomiting.
Chemical PropertiesOrange Solid
Usesantineoplastic
UsesTigecycline is a semi-synthetic tetracycline prepared by the introduction of a tert-butylaminoacetamido group into a previously unexplored and un-substituted region of existing tetracyclines. Like other tetracyclines, tigecycline acts by reversibly binding to the 30S ribosomal subunit and inhibits protein translation by blocking entry of aminoacyl-tRNA into the ribosome A site. The enhanced activity can be attributed to stronger binding affinity, thus minimising the impact of existing mechanisms of resistance. Tigecycline is regarded as the first of a new class of glycylcyline antibiotics. Critical comparison to the tetracycline class appears to be lacking in the literature.
UsesA broad spectrum glycylcycline antibiotic
UsesA glycylcycline antibiotic, used to treat infection by drug resistant bacteria such as Staphylococcus aureus (Staph aureus) and Acinetobacter baumannii.
DefinitionChEBI: Tetracycline in which the hydroxy group at position 5 and the methyl group at position 6 are replaced by hydrogen, and with a dimethylamino substituent and an (N-tert-butylglycyl)amino substituent at positions 7 and 9, respe tively. A glycylcycline antibiotic, it has activity against a broad range of Gram-positive and Gram-negative bacteria, including tetracycline-resistant organisms. It is used for the intravenous treatment of complicated skin and skin structure infections ca sed by susceptible organisms.
Tigecycline Preparation Products And Raw materials
Tag:Tigecycline(220620-09-7) Related Product Information
7-AMINO-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE 5,6,7,8-TETRAHYDRONAPHTHALENE-2-YL-ACETAMIDE 5,6,7,8-Tetrahydro-1-naphthylamine 2-NAPHTHALENAMINE, 5,6,7,8-TETRAHYDRO- 7-Monodemethyl Minocycline 2'-HYDROXY-P-ACETOTOLUIDIDE, 98 Tigecycline N,N-Dimethylacetamide 4'-CHLOROACETANILIDE Minocycline 3-Dimethylaminopropylamine 4-Acetamidophenol [4S-(4alpha,4aalpha,5aalpha,12aalpha)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxonaphthacene-2-carboxamide monohydrochloride DIACETAMIDE tert-Butanol Thioacetamide Cyclosporin A Chloroacetamide