(4-甲氧基苄基)(1-萘基甲基)胺盐酸盐
| 中文名称 | (4-甲氧基苄基)(1-萘基甲基)胺盐酸盐 |
|---|---|
| 中文同义词 | ML133 HCL (4-甲氧基苄基)(1-萘基甲基)胺盐酸盐;N-[(4-甲氧基苯基)甲基]-1-萘甲胺盐酸盐;(4-甲氧基苄基)(1-萘基甲基)胺盐酸盐;ML133盐酸盐;N-(4-甲氧基苄基)-1-(萘-1-基)甲胺盐酸盐;中文名:?(4-甲氧基苄基)(1-萘基甲基)胺盐酸盐英文名:?N-(4-METHOXYBENZYL)-1-(NAPHTHALEN-1-YL)METHANAMINE HYDROCHLORIDECAS号:1222781-70-5 |
| 英文名称 | ML 133 Hydrochloride |
| 英文同义词 | (4-Methoxybenzyl)(1-naphthylMethyl)aMine Hydrochloride;ML 133 Hydrochloride;1-(4-methoxyphenyl)-N-(naphthalen-1-ylmethyl)methanamine hydrochloride;CID 781301 hydrochloride;N-[(4-Methoxyphenyl)methyl]-1-naphthalenemethanamine hydrochloride (1:1);ML133 HCl;1-Naphthalenemethanamine, N-[(4-methoxyphenyl)methyl]-, hydrochloride (1:1);N-(4-methoxybenzyl)-1-(naphthalen-1-yl)methanamine hydrochloride |
| CAS号 | 1222781-70-5 |
| 分子式 | C19H20ClNO |
| 分子量 | 313.83 |
| EINECS号 | |
| 相关类别 | 膜转运/离子通道;离子通道;膜转运;小分子抑制剂，天然产物;Inhibitors;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 1222781-70-5.mol |
| 结构式 |  |
(4-甲氧基苄基)(1-萘基甲基)胺盐酸盐 性质
| 熔点 | 193-195°C |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：≥10mg/mL |
| 形态 | 粉末 |
| 颜色 | 白色至棕褐色 |
ML133 HCl是一种选择性钾离子通道抑制剂，作用于Kir2.1， IC50为1.8 μM (pH 7.4)和290 nM (pH 8.5)，对Kir1.1没有作用效果，对Kir4.1和Kir7.1具有微弱的作用活性。The ratio of total concentration of extracellular ML133 versus intracellular ML133 is 1:0.13 at pH 6.5, 1:9.09 at pH 8.5. ML133 is clean against 3A4 and 2C9 (IC50 >30 μM), displays moderate inhibition of 1A2 (IC50 = 3.3 μM) but proves to be a potent inhibitor of 2D6 (IC50 = 0.13 μM) in CYP450 assay. ML133 is highly protein bound (>99%) in both human and rat and also displays high intrinsic clearance in both species. ML133 (10 μM) is not displaced by K+ influx from the wild-type Kir2.1 in HEK 293 cells. M1 and/or M2 transmembrane domains contain the critical molecular determinant for ML133 inhibition of Kir2.1, especially D172 and I176.
IC50: 1.8 μM (K ir 2 at pH 7.4), 290 nM (K ir 2 at pH 8.5).
安全信息
| 危险品标志 | Xn,N |
|---|---|
| 危险类别码 | 22-37/38-41-50/53 |
| 安全说明 | 26-39-60-61 |
| 危险品运输编号 | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-100230A | (4-甲氧基苄基)(1-萘基甲基)胺盐酸盐 ML133 hydrochloride | 1222781-70-5 | 5mg | 500元 |
| 2024/01/25 | HY-100230A | (4-甲氧基苄基)(1-萘基甲基)胺盐酸盐 ML133 hydrochloride | 1222781-70-5 | 10mM * 1mLin DMSO | 550元 |