NS1652
| 中文名称 | NS1652 |
|---|---|
| 中文同义词 | 化合物NS1652;2-(3-(3-(三氟甲基)苯基)脲基)苯甲酸 |
| 英文名称 | NS1652 |
| 英文同义词 | NS1652;Benzoic acid, 2-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-;2-(3-(3-(Trifluoromethyl)phenyl)ureido)benzoic acid;Cl? Channels,NS-1652,inhibit,Inhibitor,Chloride Channel,NS1652,NS 1652 |
| CAS号 | 1566-81-0 |
| 分子式 | C15H11F3N2O3 |
| 分子量 | 324.25 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1566-81-0.mol |
| 结构式 |  |
NS1652 性质
| 熔点 | 169-171 °C |
|---|---|
| 沸点 | 355.9±42.0 °C(Predicted) |
| 密度 | 1.501±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：5 mg/mL（15.42 mM） |
| 酸度系数(pKa) | 3.51±0.36(Predicted) |
IC50: 1.6 μM (chloride channel, human and mouse red blood cell)
NS1652 potently inhibits the chloride conductance (IC 50 , 1.6 μM) in human and mouse red blood cells, but only weakly inhibits VRAC (IC 50 , 125 μM) in HEK293 cells. NS1652 markedly blocks the NO production with an IC 50 of 3.1 μM in BV2 cells. NS1652 also down-regulates iNOS expression at 3 μM, and completely abolishes at 10 μM in BV2 cells. NS1652 (0, 1.0, 3.3, 10, and 20 μM) causes increasing hyperpolarization due to inhibition of the chloride conductance in normal erythrocytes. NS1652 lowers the net KCl loss from deoxygenated sickle cells from about 12 mM cells/h to about 4 mM cells/h. NS1652 (20 μM) completely and reversiblely inhibits the red cell Cl - conductance.
NS1652 (50 mg/kg, i.v.) blocks murine erythrocyte Cl - conductance by >90% in mice.