马来酸甲麦角新碱
| 中文名称 | 马来酸甲麦角新碱 |
|---|---|
| 中文同义词 | 马来酸甲麦角新碱;马来酸甲基麦角新碱;顺丁烯二酸甲基新麦角碱;马来酸甲麦角新碱杂质;为甲基麦角系统适用性 EP标准品;马来酸甲基麦角 EP标准品;马来酸甲酯麦角新碱;化合物 T21429 |
| 英文名称 | Methylergonovine maleate salt |
| 英文同义词 | erezingen;maleicacid,methylergonovine;METHYLERGOMETRINE MALEATE;METHYLERGONOVINE MALEATE;METHYLERGONOVINE MALEATE SALT;METHYLERGONOVINE MALEIC ACID SALT;9,10-DIDEHYDRO-N-[(S)-1-(HYDROXYMETHYL)PROPYL]-6-METHYLERGOLINE-8BETA-CARBOXAMIDE MALEATE SALT;[8B(S)]-9,10-DIDEHYDRO-N-[1-(HYDROXYMETHYL)PROPYL]-6-METHYLERGOLINE-8-CARBOXAMIDE MALEATE |
| CAS号 | 57432-61-8 |
| 分子式 | C24H29N3O6 |
| 分子量 | 455.51 |
| EINECS号 | 260-734-4 |
| 相关类别 | 医药原料;原料;METHERGINE;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals |
| Mol文件 | 57432-61-8.mol |
| 结构式 |  |
马来酸甲麦角新碱 性质
| 熔点 | 1720C (dec) |
|---|---|
| 沸点 | 561.98°C (rough estimate) |
| 密度 | 1.2744 (rough estimate) |
| 折射率 | 1.6500 (estimate) |
| 储存条件 | -20°C Freezer |
| 溶解度 | 在水中的溶解度25 mg/mL |
| 颜色 | 白色 |
| 水溶解性 | Soluble to 25 mM in water |
Methylergometrine maleate (Methylergonovine maleate) 是一种麦角生物碱，是一种具有血管收缩和子宫收缩作用的 Methysergide 的活性代谢产物。Methylergometrine maleate 是一种有效的，选择性的，具有口服活性的 5-HT 受体拮抗剂，pA2 值为 9.6。Methylergometrine maleate 具有抗偏头痛和多巴胺能活性，可用于预防和控制产后出血。
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serotonin 9.6 nM (pA2) |
Both Methysergide and Methylergometrine displace the concentration-response curve of 5-HT to the right and depressed the maximum effect ; thus, both agents behaved as non-competitive antagonists of 5-HT. Methylergometrine is approximately 40-times more potent than Methysergide as an antagonist of the 5-HT-induced responses, since the calculated apparent pA2 values are 9.6 and 8.0, respectively.
Methylergometrine is more potent than Methysergide as a vasoconstrictor on bovine middle cerebral artery and human coronary arteries, an effect on 5-HT1B receptors. Subacute oral administration would result in metabolism of Methysergide to Methylergometrine.
安全信息
| 危险品标志 | T |
|---|---|
| 危险类别码 | 23/24/25-62 |
| 安全说明 | 36/37/39-45 |
| 危险品运输编号 | UN 1544 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS号 | KE5500000 |
| 危险等级 | 6.1(b) |
| 包装类别 | III |
| 海关编码 | 2939690000 |
| 提供商 | 语言 |
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-100988 | 马来酸甲麦角新碱 Methylergometrine maleate | 57432-61-8 | 5mg | 1300元 |
| 2024/01/25 | HY-100988 | 马来酸甲麦角新碱 Methylergometrine maleate | 57432-61-8 | 10mM * 1mLin DMSO | 1430元 |