| Chemical Properties | white crystalline powder |
| Uses | Propantheline is an antimuscarinic agent used in the treatment of hyperhidrosis (excessive sweating), enuresis (involuntary urination) as well as cramps or spasms of the stomach, intestine and bladder. |
| Uses | A muscarinic acetylcholine receptor antagonist |
| Uses | anticholinergic |
| Definition | ChEBI: Propantheline bromide is a member of xanthenes. |
| Brand name | Pro-Banthine (Searle). |
| General Description | Propantheline bromide,2-hydroxy-ethyl)diisopropylmethylammonium bromidexanthene-9-carboxylate (Pro-Banthine), is prepared in amanner exactly analogous to that used for methanthelinebromide. It is a white, water-soluble, crystalline substance,with properties quite similar to those of methantheline bromide.Its chief difference from methantheline bromide is inits potency, which has been estimated variously to be 2 to5 times as great. |
| General Description | White crystals or white powder. Melting point 159-161°C .Used therapeutically as an anticholinergic. |
| Air & Water Reactions | Water soluble. |
| Health Hazard | SYMPTOMS: Symptoms of exposure to Propantheline bromide include dilated pupils and blurred vision; increased intraocular tension and heart rate; hot, dry, red skin; dry mouth; disorientation; hallucinations; aggressive behavior; rapid pulse and respiration; convulsions; and coma. |
| Fire Hazard | Flash point data are not available for Propantheline bromide , but Propantheline bromide is probably combustible. |
| Biochem/physiol Actions | Inhibits action of acetylcholine at post-ganglionic synapses; muscarinic acetylcholine receptor antagonist; antispasmodic; reduces gastric acid secretion. |
| Veterinary Drugs and Treatments | In small animal medicine propantheline bromide has been used for
its antispasmodic/antisecretory effects in the treatment of diarrhea.
It is also employed in the treatment of hyperreflexic detrusor or
urge incontinence and as oral treatment in anticholinergic responsive
bradycardias. In horses, propantheline has been used intravenously
to reduce colonic peristalsis and for relaxing the rectum to
allow easier rectal examination and surgery. |