MLN-4760
| 中文名称 | MLN-4760 |
|---|---|
| 中文同义词 | 化合物MLN-4760;((S)-1-羧基-2-(1-(3,5-二氯苄基)-1H-咪唑-5-基)乙基)-L-亮氨酸 |
| 英文名称 | MLN-4760 |
| 英文同义词 | MLN-4760;L-Histidine, N-[(1S)-1-carboxy-3-methylbutyl]-3-[(3,5-dichlorophenyl)methyl]-;((S)-1-carboxy-2-(1-(3,5-dichlorobenzyl)-1H-imidazol-5-yl)ethyl)-L-leucine;inhibit,Angiotensin-converting Enzyme (ACE),MLN 4760,Inhibitor,MLN-4760,MLN4760 |
| CAS号 | 305335-31-3 |
| 分子式 | C19H23Cl2N3O4 |
| 分子量 | 428.31 |
| EINECS号 | |
| 相关类别 | 氨基酸 |
| Mol文件 | 305335-31-3.mol |
| 结构式 |  |
MLN-4760 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 可溶于DMSO |
| 形态 | 固体 |
| Target | Value |
|
ACE2
(Cell-free assay) | 0.44 nM |
|
CPDA
(Cell-free assay) | 27 μM |
MLN-4760 is a potent and selective human ACE2 inhibitor (IC 50 , 0.44 nM), with excellent selectivity (>5000-fold) versus related enzymes human testicular ACE (IC 50 , >100 μM) and bovine carboxypeptidase A (CPDA; IC 50 , 27 μM). MLN-4760 effectively quenches cleavage of the 7-Mca-YVADAPK(Dnp) in rhACE2. MLN-4760 shows pIC 50 at rhACE2 of 8.5±0.1 and at rhACE of 4.4±0.2. MLN-4760 also shows pIC 50 at rhACE2 of 4.7±0.1, 6.9±0.1 and at ACE of 4.4±0.1, 6.2±0.1 in murine heart and mononuclear cells (MNCs), resepctively.
MLN-4760 (100 μM, intracerebroventricular infusion for five days) significantly worsens neurological function at 4 h and 3 d post-stroke without significantly increasing infarct volume.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-19414 | MLN-4760 MLN-4760 | 305335-31-3 | 1mg | 1550元 |
| 2024/04/30 | HY-19414 | MLN-4760 MLN-4760 | 305335-31-3 | 5mg | 3150元 |