HEXAMETHONIUM CHLORIDE

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Company Name: JinOu Biomedical (Nanjing) Co., Ltd.  
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Products Intro: CAS:60-26-4
Purity:98% Package:1g/10g/100g/500g/1kg/5kg/
Company Name: Changzhou Bojia Biomedical Technology Co., Ltd.  
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Products Intro: CAS:60-26-4
Purity:98% Package:100mg/1g/10g/100g/1kg
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Products Intro: Product Name:HEXAMETHONIUM CHLORIDE
CAS:60-26-4
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Products Intro: Product Name:Hexamethonium
CAS:60-26-4
Company Name: SynZeal Research Pvt Ltd  
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Products Intro: Product Name:Hexamethonium
CAS:60-26-4
HEXAMETHONIUM CHLORIDE Basic information
Product Name:HEXAMETHONIUM CHLORIDE
Synonyms:benzohexamethonium;bistrium;esametonio;hexamethonium;hexamethylenebis(trimethyl-ammoniu;hexane-1,6-bis(trimethylammonium);hexanium;n,n,n,n’,n’,n’-hexamethyl-6-hexanediaminium
CAS:60-26-4
MF:C12H30N2+2
MW:202.38
EINECS:
Product Categories:
Mol File:60-26-4.mol
HEXAMETHONIUM CHLORIDE Structure
HEXAMETHONIUM CHLORIDE Chemical Properties
Safety Information
MSDS Information
HEXAMETHONIUM CHLORIDE Usage And Synthesis
OriginatorBistrium,Squibb,US,1951
DefinitionChEBI: Hexamethonium is a quaternary ammonium salt.
Manufacturing ProcessHexamethylene diamine (116 g), sodium carbonate (466 g), and water (800 ml) were heated to 60°C, and dimethyl sulfate (830 g) added with stirring over 1% hours keeping the temperature below 90°C. The reaction mixture was then stirred at 90°C for 2 hours, then cooled to 20°C, acetone (1,200 ml) added and the whole cooled to 0°C.
The solid formed was removed by filtration and washed with acetone (150 ml). Filtrate and washings were diluted with water to 4 liters and heated to 60°C under reflux. To this was added a solution prepared from embonic acid (388 g), sodium hydroxide (80 g) and water (5 liters), the whole refluxed for 10 minutes and thereafter allowed to cool overnight.
The resultant embonate (530 g) was filtered off, washed twice with a solution of acetone (75 ml) in water (425 ml), and dried at 100°C to give an amorphous yellow powder, MP 290°C to 291°C (with decomp.). 588 g of the embonate was dissolved in boiling water (4 liters).
Hydrobromic acid 50% w/w (325 g) diluted with water (2 liters) was added slowly at the boil and the precipitated embonic acid removed by filtering hot and washing twice with hot water (1 liter). The filtrate and washings were evaporated to dryness in a steam pan and the residue recrystallized from ethyl alcohol (1,200 ml), to yield the dibromide (320 g).
Therapeutic FunctionAntihypertensive
HEXAMETHONIUM CHLORIDE Preparation Products And Raw materials
Raw materialsSodium hydroxide-->Hexamethylenediamine-->Dimethyl sulfate-->Hydrogen bromide
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