ChemicalBook > Product Catalog >API >Nervous system drugs >Drug Metabolism in Human Brain >ALMITRINE

ALMITRINE

ALMITRINE Suppliers list
Company Name: career henan chemical co
Tel: +86-0371-86658258 15093356674;
Email: factory@coreychem.com
Products Intro: Product Name:almitrine
CAS:27469-53-0
Purity:Min98% HPLC Package:1KG;1USD
Company Name: SIMAGCHEM CORP
Tel: +86-13806087780
Email: sale@simagchem.com
Products Intro: Product Name:Almitrine Dimesylate
CAS:27469-53-0
Purity:0.99 Package:1kg,5kg,25kgs,200kgs;bulk
Company Name: Dideu Industries Group Limited
Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Products Intro: Product Name:ALMITRINE
CAS:27469-53-0
Purity:99.9% Package:1g;1.1USD Remarks:FDA GMP CEP Approved Manufacturer
Company Name: LUYUNJIA CHEMISTRY XIAMEN LIMITED
Tel: +86-592-5360779 +86-13055435203
Email:
Products Intro: Product Name:ALMITRINE
CAS:27469-53-0
Purity:99% Package:25KG/drum or as client request
Company Name: Hebei Duling International Trade Co. LTD
Tel: +8618032673083
Email: sales05@hbduling.cn
Products Intro: Product Name:ALMITRINE
CAS:27469-53-0
Purity:99% Package:1kg;45USD

ALMITRINE manufacturers

  • ALMITRINE
  • ALMITRINE pictures
  • $45.00 / 1kg
  • 2023-02-24
  • CAS:27469-53-0
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 5000 tons
  • ALMITRINE USP/EP/BP
  • ALMITRINE USP/EP/BP pictures
  • $1.10 / 1g
  • 2021-07-28
  • CAS:27469-53-0
  • Min. Order: 1g
  • Purity: 99.9%
  • Supply Ability: 100 Tons min
  • almitrine
  • almitrine pictures
  • $1.00 / 1KG
  • 2020-02-01
  • CAS:27469-53-0
  • Min. Order: 1KG
  • Purity: Min98% HPLC
  • Supply Ability: G/KG/TON
ALMITRINE Basic information
Product Name:ALMITRINE
Synonyms:ALMITRINE;1-[2,4-Bis(allylamino)-1,3,5-triazin-6-yl]-4-[bis(4-fluorophenyl)methyl]piperazine;2,4-Bis(allylamino)-6-[4-[bis(p-fluorophenyl)methyl]-1-piperazinyl]-s-triazine;6-[4-[Bis(4-fluorophenyl)methyl]-1-piperazinyl]-N,N'-di(2-propenyl)-1,3,5-triazine-2,4-diamine;S-2620;AlMitrine Mesylate;Almitrine dimethanesulfonic acid;1,3,5-Triazine-2,4-diamine, 6-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]-N2,N4-di-2-propen-1-yl-
CAS:27469-53-0
MF:C26H29F2N7
MW:477.55
EINECS:248-475-5
Product Categories:
Mol File:27469-53-0.mol
ALMITRINE Structure
ALMITRINE Chemical Properties
Melting point 181°
density 1.2278 (estimate)
form Solid
Safety Information
ToxicityLD50 ipr-mus: 390 mg/kg DRFUD4 3,717,78
MSDS Information
ALMITRINE Usage And Synthesis
OriginatorArmanor ,Les Laboratoires Servier
UsesRespiratory stimulant.
DefinitionChEBI: A triamino-1,3,5-triazine compound having allylamino substituents at the 2- and 4-positions and a 4-(bis(p-fluorophenyl)methyl)-1-piperazinyl group at the 6-position.
Manufacturing ProcessA solution of 4,6-bis(allylamino)-2-chloro-s-triazine, melting point 204°C (Kofler) and dihydrochloride of 1-p,p'-difluorobenzhydryl piperazine, melting point 178°-180°C (capillary) in anhydrous dimethylformamide are heated under reflux. On completion of this operation the solvent is removed under vacuum and the residue taken up in a mixture of chloroform and of water (1:1). The organic phase is separated, and repeatedly extracted with aqueous N-methanesulphonic acid and the aqueous acidic layers separated. The aforementioned acidic solutions are then combined and rendered alkaline (pH 10) with dilute aqueous sodium hydroxide, the base extracted with ether, the extract dried over anhydrous potassium carbonate, and filtered. The etheral filtrate, upon evaporation yields the 2,4-bis(allylamino)-6-(4-(bis(pfluorophenyl) methyl)-1-piperazinyl)-s-triazine, melting point 175°-180°C.
Brand nameVectarion (Oril S.A., France).
Therapeutic FunctionRespiratory stimulant
World Health Organization (WHO)Peripheral neuropathy has been reported in a few patients receiving almitrine for long periods. The indications for treatment have consequently been restricted in the Federal Republic of Germany. Some other countries have advised doctors to maintain patients under close supervision throughout treatment and to restrict dosage to two out of every three months.
PharmacologyAlmitrine, like doxapram, increases the rate and depth of respiration. In addition, it is believed that it redistributes pulmonary blood circulation, increasing it in alveoli, which leads to relatively better pulmonary ventilation. It has a more prolonged effect than doxapram.
Safety ProfilePoison by intraperitoneal andintravenous routes. When heated to decomposition itemits very toxic fumes of F?? and NOx.
SynthesisAlmitrine, 2,4-bis (allylamino)-6-[4-[bis-(p-fluorophenyl)methyl]-1-piperazinyl]-s-triazine (8.2.6), is synthesized by reacting 1-[bis-(p-fluorophenyl)methyl]piperazine with cyanuric chloride, which gives 2,4-dichloro-6-[4-[bis-(p-fluorophenyl) methyl]-1-piperazinyl]-s-trazine (8.2.5). Reacting this with allylamine gives almitrine (8.2.6) [19¨C22].

Synthesis_27469-53-0

ALMITRINE Preparation Products And Raw materials
Raw materialsSodium hydroxide
Tag:ALMITRINE(27469-53-0) Related Product Information
TRIAZINONE almitrine-raubasine TRIETAZINE-ETHYLAMINO Melamine hydrogen flouride 4,4'-Difluorobenzhydrylpiperazine 1-(4-FLUORO-ALPHA-PHENYLBENZYL)PIPERAZINE (R)-1-(4-Fluorophenyl)ethylamine 1-(1,3,5-TRIAZIN-2-YL)PIPERAZINE (S)-N-METHYL-1-(4-FLUOROPHENYL)ETHYLAMINE ALMITRINE BISMESYLATE,ALMITRINE DIMESYLATE,ALMITRINE DIMESILATE 1-(4-FLUOROBENZYL)PIPERAZINE (R)-N-METHYL-1-(4-FLUOROPHENYL)ETHYLAMINE 1-[1-(4-FLUORO-PHENYL)-ETHYL]-PIPERAZINE ALMITRINE (S)-1-(4-FLUOROPHENYL)ETHYLAMINE (4-fluorophenyl)(phenyl)methylamine