硫黄素 T
中文名称 | 硫黄素 T |
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中文同义词 | 2-[4-(二甲基氨基)苯基]-3,6-二甲基苯并噻唑鎓氯化物;碱性黄1;硫代磺素T;硫黄素 T;盐基嫩黄;硫磺素T;硫代黄素T;2-[4-(二甲基氨基)苯基]-3,6-二甲基苯并噻唑氯化物 |
英文名称 | Thioflavine T |
英文同义词 | 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-benzothiazoliuchloride;Benzothiazolium,2-[4-(dimethylamino)phenyl]-3,6-dimethyl-,chloride;Thioflavine T (C.I.No.49005) for synthesis;LABOTEST-BB LT00451909;BASIC YELLOW 1;CI 49005;CI NO 49005;SETOFLAVINE T |
CAS号 | 2390-54-7 |
分子式 | C17H19ClN2S |
分子量 | 318.86 |
EINECS号 | 219-228-9 |
相关类别 | 有机硼化合物;色素类;生化试剂;化工原料;其他生化试剂;生化试剂-色素类;Biochemistry;Vitamin Derivatives;Vitamins;化学试剂;电镀原材料;功能性添加剂化工原料;电镀添加剂;有机化工原料;通用生化试剂-生物染色剂与化学指示剂;化学合成新材料;工业化;酸铜中间体 |
Mol文件 | 2390-54-7.mol |
结构式 |
硫黄素 T 性质
熔点 | 211-212 °C (decomp) |
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密度 | 1.301g/cm3 at 20℃ |
蒸气压 | 0Pa at 25℃ |
储存条件 | Store below +30°C. |
溶解度 | 在甲醇中可溶1mg/mL |
色指数 | 49005 |
形态 | 粉末 |
颜色 | 黄色至黄褐色 |
BRN | 3922452 |
LogP | 3.02 at 25℃ and pH7.98 |
CAS 数据库 | 2390-54-7(CAS DataBase Reference) |
EPA化学物质信息 | Benzothiazolium, 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-, chloride (2390-54-7) |
Thioflavin T (ThT) is a benzothiazole dye that exhibits enhanced fluorescence upon binding to amyloid fibrils and is commonly used to diagnose amyloid fibrils, both ex vivo and in vitro. In aqueous solutions, Thioflavin T is found to exist as micelles at concentrations commonly used to monitor fibrils by fluorescence assay (~10-20 μM). Specific conductivity changes are measured at varying concentration of Thioflavin T and the critical micellar concentration is calculated to be 4.0±0.5 μM. Changes in the fluorescence excitation and emission of Thioflavin T are also dependent on the micelle formation. The Thioflavin T micelles of 3 nm diameter are directly visualized using atomic force microscopy, and bound Thioflavin T micelles are observed along the fibril length for representative fibrils. Increasing concentration of Thioflavin T above the critical micellar concentration shows increased numbers of micelles bound along the length of the amyloid fibrils. Thioflavin T micelles are disrupted at low pH as observed by atomic force microscopy and fluorescence enhancement upon binding of Thioflavin T to amyloid fibrils also reduced by several-fold upon decreasing the pH to below 3.The micelles of Thioflavin T bind amyloid fibrils leading to enhancement of fluorescence emission.
安全信息
安全说明 | 24/25 |
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危险品运输编号 | 2811 |
WGK Germany | 3 |
TSCA | Yes |
危险等级 | 6.1(b) |
包装类别 | III |
海关编码 | 32041300 |
提供商 | 语言 |
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