莰菲醇-3-O-芸香糖苷
| 中文名称 | 莰菲醇-3-O-芸香糖苷 |
|---|---|
| 中文同义词 | 山柰酚-3-O-芸香糖苷(烟花苷,莰菲醇-3-O-芸香糖苷,莰非醇-3-O-芸香糖苷);山柰酚-3-O-芸香糖苷;莰菲醇-3-O-芸香糖苷;莰非醇-3-O-芸香糖苷;山柰酚-3-O-芸香糖苷(标准品);烟花苷;山柰酚-3-O-芸香糖苷, 来源于红花;烟花苷,莰菲醇-3-O-芸香糖苷,莰非醇-3-O-芸香糖苷 |
| 英文名称 | KAEMPFEROL-3-O-RUTINOSIDE |
| 英文同义词 | KaeMpferol-3-O-rutinoside, Nicotiflorin;3,4′,5,7-Tetrahydroxyflavone 3-rhamnoglucoside;KaeMpferol-3-O-rutinosid, froM CarthaMus tinctorius;KAEMPFEROL-3-O-RUTINOSIDE;Kaempfeol-3-O-rutinoside;KAEMPFEROL-3-O-RUTINOSIDE WITH HPLC;KAEMPFEROL-3-RUTINOSIDE hplc;3-[[6-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2-(4-hydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one |
| CAS号 | 17650-84-9 |
| 分子式 | C27H30O15 |
| 分子量 | 594.52 |
| EINECS号 | |
| 相关类别 | 对照品;标准品;植物提取物;中药对照品;植提标准品;类黄酮;化学连接;标准品-中药标准品;Tetra-substituted Flavones;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;对照品-中药对照品;黄酮;标准品 -中药标准品;标准品，对照品;黄金产品 |
| Mol文件 | 17650-84-9.mol |
| 结构式 |  |
莰菲醇-3-O-芸香糖苷 性质
| 熔点 | 200°C (dec.) |
|---|---|
| 沸点 | 941.7±65.0 °C(Predicted) |
| 密度 | 1.76 |
| 储存条件 | Inert atmosphere,Store in freezer, under -20°C |
| 溶解度 | 可溶于氯仿（少许）、DMSO（少许）、甲醇（少许） |
| 形态 | 固体 |
| 酸度系数(pKa) | 6.20±0.40(Predicted) |
| 颜色 | 灰白色至黄色 |
| 稳定性 | 吸湿性 |
| Target | Value |
|
p-JAK2
() | |
|
p-STAT3
() | |
|
caspase-3
() | |
|
Bax
() | |
|
Bcl-2
() |
For primarily cultured neurons suffered 2 h hypoxia followed by 24 h reoxygenation, nicotiflorin significantly attenuates cell death and reduces LDH release. Morphological observation also directly confirms its protective effect on neuron. After total 4 h hypoxia and 12 h reoxygenation, eNOS activity, mRNA and protein levels in the primarily cultured rat cerebral blood vessel endothelial cells treated with nicotiflorin (25-100 g/mL) 2 h after onset of hypoxia are significantly higher than eNOS activity, mRNA and protein levels in the pure H-R cells and also higher than eNOS activity, mRNA and protein levels in cells cultured under normoxic conditions.
At doses of 2.5, 5 and 10 mg/kg, nicotiflorin administered immediately after the onset of ischemia markedly reduces brain infarct volume and neurological deficits. Nicotiflorin (2.5-10 mg/kg) administered after onset of ischemia markedly reduces brain infarct volume by 24.5-63.2% and neurological deficits.
药理药效:降血脂、善痴呆症状和记忆保护
安全信息
| 危险品标志 | Xn |
|---|---|
| 危险类别码 | 22 |
| 安全说明 | 22-45-24/25 |
| WGK Germany | 3 |
| 海关编码 | 29389090 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-N1475 | 莰菲醇-3-O-芸香糖苷 Nicotiflorin | 17650-84-9 | 5mg | 2200元 |
| 2024/01/25 | HY-N1475 | 莰菲醇-3-O-芸香糖苷 Nicotiflorin | 17650-84-9 | 10mM * 1mLin DMSO | 2420元 |