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| | 2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine Basic information |
| Product Name: | 2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine | | Synonyms: | 1,5-dihydropyrimido[5,4-d]pyrimidine-2,4,6,8(3H,7H)tetrone;2,6,8,10-Tetrahydroxy-homopurine;2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine;Homouric;homouric acid;1,2,3,4,5,6,7,8-Octahydropyrimido[5,4-d]pyrimidine-2,4,6,8-tetrone;Pyrimido[5,4-d]pyrimidine-2,4,6,8(1H,3H,5H,7H)-tetrone;Pyrimido[5,4-d]pyrimidine-2,4,6,8-tetrol | | CAS: | 6713-54-8 | | MF: | C6H4N4O4 | | MW: | 196.12 | | EINECS: | 229-766-6 | | Product Categories: | Heterocycle-Pyrimidine series | | Mol File: | 6713-54-8.mol |  |
| | 2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine Chemical Properties |
| density | 1.89±0.1 g/cm3(Predicted) | | pka | 5.90±0.20(Predicted) |
| | 2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine Usage And Synthesis |
| Uses | 2,4,6,8-Tetrahydroxy-Pyrimido(5,4-d)Pyrimidine is a pharmaceutical intermediate used in the preparation of Dipyridamole, an antiplatelet drug that is used primarily in the treatment of ischaemic heart disease and stroke. 2,4,6,8-Tetrahydroxy-Pyrimido(5,4-d)Pyrimidine is also used as a herbicide to control broadleaf weeds in wheat crops. | | Synthesis | 2,4,6,8-Tetrahydroxy-Pyrimido-(5,4d)Pyrimidine is prepared by the reaction of 5-amino-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid and urea. The specific synthesis steps are as follows:
5-amino-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid was charged into a two nicked flask, Urea (7.7 g, 128.0 mmol) was added dropwise with 125 ml of NaOH solution (500 g of sodium hydroxide + 1500 g of purified water) After dripping rapidly warming to 100 ° C,Insulation for one hour; continue to stir 3h,(25 ° C), filtered to obtain a solid, add purified water 250ml, heated to 60 ° C, heat lh, and then add dilute hydrochloric acid to ΡΗ = 4, cooled to room temperature filtration, washed and dried to obtain pyrimidine [5 , 4-d] pyrimidine-2,4,6,8-tetraol (tetrahydroxy), and recrystallized (ethanol solvent) to give 10.9 g in 86.9% yield.
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| | 2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine Preparation Products And Raw materials |
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