化合物 T15800
| 中文名称 | 化合物 T15800 |
|---|---|
| 中文同义词 | 化合物 T15800 |
| 英文名称 | Phenethipylone |
| 英文同义词 | Phenethipylone;LY 117018;[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl][4-[2-(1-pyrrolidinyl)ethoxy]phenyl]methanone;6-Hydroxy-2-(4-hydroxyphenyl)benzo(B)thien-3-yl 4-(2-(1-pyrrolidinyl)ethoxy) phenyl ketone;Lilly 117018;Ly 139478;Methanone, (6-hydroxy-2-(4-hydroxyphenyl)benzo(B)thien-3-yl)(4-(2-(1-pyrrolidinyl)ethoxy)phenyl)-;[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanone |
| CAS号 | 63676-25-5 |
| 分子式 | C27H25NO4S |
| 分子量 | 459.56 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 63676-25-5.mol |
| 结构式 |  |
化合物 T15800 性质
LY117018，Raloxifene 类似物，是一种选择性雌激素受体 (estrogen receptor) 调节剂。LY117018 对乳腺癌细胞具有抗增殖作用。
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Estrogen receptor
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LY117018 (0.01-1000 nM; 24 hours) at lower concentrations (0.01-10 nM) caused an E2-like increase in p53 levels when compared to its effects on cells grown in the stripped medium. At a higher concentration of LY117018 (1 μM), the level of p53 appeared to decline. Treatment with 1 μM LY117018 resulted in a predominantly hypophosphorylated pRb. At lower concentrations, LY117018 did not block E2-induced pRb phosphorylation.
LY117018 (1 μM; 96 hours) inhibits MCF-7 cells proliferation with an IC
50
of 1 μM.
LY117018 suppresses oxidative stress-induced endothelial cell apoptosis through activation of ERK1/2 signaling pathway.
Cell Proliferation Assay
| Cell Line: | MCF-7 cells |
| Concentration: | 1 μM |
| Incubation Time: | 96 hours |
| Result: | Inhibited MCF-7 cells proliferation with an IC 50 of 1 μM. |