银杏内酯 C
| 中文名称 | 银杏内酯 C |
|---|---|
| 中文同义词 | 白果苦内酯C,1Β,7Β-二羟基银杏内酯A;银杏内酯C(白果苦内酯C,1Β,7Β-二羟基银杏内酯A);GINKGOLIDE C 银杏内酯C;银杏内酯C(标准品);白果苦内酯 C;银杏内酯 C;银杏内酯C(分析标准品);银杏内酯 C, 来源于银杏 |
| 英文名称 | Ginkgolide C |
| 英文同义词 | GINKGOLIDE C;1,7-DIHYDROXY-GINKGOLIDE A;(1S,2R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)-3-(1,1-Dimethylethyl)hexahydro-2,4,7b,11-tetrahydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione;Gingkolide C;bn52022;GinkgolideA,1,7-dihydroxy-, (1α,7β)-;CGinkgolid;Ginkgolide C,1,7-Dihydroxy-ginkgolide A |
| CAS号 | 15291-76-6 |
| 分子式 | C20H24O11 |
| 分子量 | 440.4 |
| EINECS号 | |
| 植物来源 | 银杏 |
| 相关类别 | 中药对照品;标准品;生化试剂;对照品,标准品;分析标准品;植物提取物;对照品;植提标准品;中药标准品;小分子抑制剂;小分子抑制剂，天然产物;标准品-对照品;标准品，对照品;标准品-中药标准品;二萜;Saponins;Intermediates & Fine Chemicals;Pharmaceuticals;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;标准品 -中药标准品;分析试剂-标准品;通用生化试剂-天然产物 |
| Mol文件 | 15291-76-6.mol |
| 结构式 |  |
银杏内酯 C 性质
| 熔点 | >3000 (dec) |
|---|---|
| 比旋光度 | D24 -14.7° (c = 1 in ethanol) |
| 沸点 | 813.8±65.0 °C(Predicted) |
| 密度 | 1.72±0.1 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,Store in freezer, under -20°C |
| 溶解度 | 可溶于DMSO（轻微）、乙醇（轻微、超声处理）、甲醇（轻微、加热） |
| 酸度系数(pKa) | 10.88±0.70(Predicted) |
| 颜色 | 白色至类白色 |
| LogP | 1.719 (est) |
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AMPK
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MMP-9
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Human Endogenous Metabolite
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Sirtuin
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Ginkgolide C (3-100 μM) has no significant effect on 3T3-L1 cell viability, but suppresses adipogenesis in 3T3-L1 cells followling 24 h treatment. Ginkgolide C (10-100 μM) significantly suppresses lipid accumulation compared with the control group and also significantly promotes glycerol release in 3T3-L1 adipocytes. Ginkgolide C suppresses PPAR-α and PPAR-γ expression and decreases C/EBPα, C/EBPβ, and SREBP-1c expression in differentiated 3T3-L1 adipocytes. In addition, Ginkgolide C (3-100 μM) suppress adipogenesis-related protein (FAS, LPL, and aP2) and mRNA expression in a dose-dependent manner in differentiated 3T3-L1 adipocytes. Ginkgolide C (3-100 μM) also significantly promotes Sirt1 production and increases phosphorylation of AMPKα and ACC-1 in a concentration-dependent manner. Ginkgolide C (1, 10, 50, 100, 500 mM) significantly reduces the collagen (10 mg/mL)-stimulated rat platelet aggregation in a dose-dependent manner. Ginkgolide C (50, 100 mM) causes pro-MMP-9 (92-kDa) to form an activated MMP-9 (86-kDa) in collagen-stimulated platelets.
药理药效:银杏内酯C对治疗心、脑血管疾病有很好的辅助作用。
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-N0785 | Ginkgolide C | 5 mg | 510元 | |
| 2024/01/25 | HY-N0785 | 银杏内酯 C Ginkgolide C | 15291-76-6 | 10mg | 530元 |