(E)-3-(3H-咪唑-4-基)丙-2-烯酸
中文名称 | (E)-3-(3H-咪唑-4-基)丙-2-烯酸 |
---|---|
中文同义词 | (E)-3-(3H-咪唑-4-基)丙-2-烯酸;顺 - 尿刊酸;顺式-尿刊酸;顺-咪唑丙烯酸;化合物 T10824;顺式-尿烷酸 |
英文名称 | (E)-3-(3H-imidazol-4-yl)prop-2-enoic acid |
英文同义词 | (E)-3-(3H-imidazol-4-yl)prop-2-enoic acid;cis-Urocanic acid;cis-3-(1H-imidazol-4-yl)-2-propenoic acid, cis-UCA;(2Z)-3-(1H-Imidazole-4-yl)acrylic acid;(Z)-3-(1H-Imidazol-4-yl)propenoic acid;(Z)-3-(1H-Imidazole-4-yl)acrylic acid;(Z)-Urocanic acid;(αZ)-1H-Imidazole-4-acrylic acid |
CAS号 | 7699-35-6 |
分子式 | C6H6N2O2 |
分子量 | 138.12 |
EINECS号 | |
相关类别 | Isolabel |
Mol文件 | 7699-35-6.mol |
结构式 |
(E)-3-(3H-咪唑-4-基)丙-2-烯酸 性质
熔点 | 175-176 °C |
---|---|
沸点 | 456.9±20.0 °C(Predicted) |
密度 | 1.430±0.06 g/cm3(Predicted) |
储存条件 | -20°C |
溶解度 | H2O:>10mg/mL |
形态 | 固体(蓬松的) |
酸度系数(pKa) | 2.82±0.28(Predicted) |
颜色 | 白色 |
水溶解性 | Soluble in water |
敏感性 | Light Sensitive |
5-HT 2A Receptor
|
Treatment with 100 μg/mL cis-Urocanic acid (cis-UCA) completely suppresses IL-6 and IL-8 secretion, decreases caspase-3 activity, and improves cell viability against UV-B irradiation. No significant effects on IL-6 or IL-8 secretion, caspase-3 activity, or viability of the non-irradiated cells are observed with 100 μg/mL cis-Urocanic acid in both cell types. The 5000 μg/mL concentration is toxic.
Cell Viability Assay
Cell Line: | Human corneal epithelial cells (HCE-2) and human conjunctival epithelial cells (HCECs) |
Concentration: | 10, 100, 1,000, and 5,000 μg/mL |
Incubation Time: | 24, 48, or 72 hours |
Result: | Treatment with 100 μg/mL completely suppressed IL-6 and IL-8 secretion, decreased caspase-3 activity, and improved cell viability against UV-B irradiation. No significant effects on IL-6 or IL-8 secretion, caspase-3 activity, or viability of the non-irradiated cells were observed with 100 μg/mL in both cell types. |
安全信息
安全说明 | 22-24/25 |
---|---|
WGK Germany | 3 |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/04/30 | HY-113008A | cis-Urocanic acid | 1 mg | 2133元 | |
2024/04/30 | HY-113008A | (E)-3-(3H-咪唑-4-基)丙-2-烯酸 cis-Urocanic acid | 7699-35-6 | 5mg | 4200元 |