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| | trans-4-Aminocyclohexanol Chemical Properties |
| Melting point | 108-113°C | | Boiling point | 127 °C / 14mmHg | | density | 0.9837 (rough estimate) | | refractive index | 1.4713 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Crystals | | pka | 15.12±0.40(Predicted) | | color | White to almost white | | Water Solubility | Soluble in water. | | Sensitive | Hygroscopic | | LogP | -0.4 | | CAS DataBase Reference | 27489-62-9(CAS DataBase Reference) |
| | trans-4-Aminocyclohexanol Usage And Synthesis |
| Description | Trans-4-Aminocyclohexanol is also named as Cis-4-Aminocyclohexanol. It was a medical intermediate of ambroxol, which is used in the treatment of respiratory diseases associated with viscid or excessive mucus.1 It is used as a raw material in organic synthesis, such as in the synthesis of N-substituted 7-azabicyclo [2.2.1] hepatanes, which are good substrates for microbial oxidation of unactivated carbons by B.bassiana.2
| | Reference |
- Y. Jian, Improved Process of the Synthesis of Trans-4-aminocyclohexanol, Fine Chemicals, 2000, vol. 2
- H. F. Olivo, M. S. Hemenway, M. H. Gezginci, Synthesis and Microbial Hydroxylation of Some Azabicycloalkanes, Tetrahedron Letters, 1998, vol. 39, pp. 1309-1312
| | Chemical Properties | white to light yellow crystal powder | | Uses | trans-4-Aminocyclohexanol is used as raw material in organic synthesis and is an important intermediate in the synthesis of drugs such as Ambroxol hydrochloride. It can react with butyric acid-(2-chloro-ethyl ester) to get butyric acid 4-amino-cyclohexyl ester. This reaction needs catalytic agent Aspergillus niger lipase and solvent 2-methyl-butan-2-ol. | | Uses | trans-4-aminocyclohexanol be used as organic intermediates. |
| | trans-4-Aminocyclohexanol Preparation Products And Raw materials |
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