二苯甲酰基甲烷
| 中文名称 | 二苯甲酰基甲烷 |
|---|---|
| 中文同义词 | ω-苯甲酰基苯乙酮;二苯甲酰甲烷;二苯甲酰基甲烷;二苯甲酰基甲烷, 97+%;1,3-二苯基丙二酮 DBM;二苯甲酰基甲烷(DMB);1,3-二苯基-1,3-丙二酮/二苯甲酰甲烷/DBM;二苯甲酰甲烷(DBM) |
| 英文名称 | Dibenzoylmethane |
| 英文同义词 | ,3-Diphenyl-propane-1,3-dione;1,3-Diphenyl-1,3-propanediamine;Phenyl-hydroxystyrylketone;rhodiastab83;DIBENZOYLMETHANE;1,3-Diphenyl-1,3-propanedione~Dppd-H;DIBENZOYLMMETHANE 98% (GC) &;Dibenzoylmethane,>99% |
| CAS号 | 120-46-7 |
| 分子式 | C15H12O2 |
| 分子量 | 224.25 |
| EINECS号 | 204-398-9 |
| 相关类别 | 细胞生物学;有机化工;医药原料;生物活性小分子;苯甲酰;Beta二酮;酮;塑料制造;化工原料;化工产品-有机化工;有机化工原料;无机化工原料;有机化工原料;日用化学品原料;其他原料;Color Former & Related Compounds;Functional Materials;Sensitizer;Slight yellowish crystalline powder;原料;大化工;化工材料;化工原料-表面活性剂;精细化工原料;其他有机精细化工原料;化工中间体;有机原料 |
| Mol文件 | 120-46-7.mol |
| 结构式 |  |
二苯甲酰基甲烷 性质
| 熔点 | 77-79 °C(lit.) |
|---|---|
| 沸点 | 219-221 °C18 mm Hg(lit.) |
| 密度 | 0.800 g/cm3 |
| 蒸气压 | 0.01Pa at 20℃ |
| 折射率 | 1.6600 (estimate) |
| 闪点 | 219-221°C/18mm |
| 储存条件 | Store below +30°C. |
| 溶解度 | 可溶于氯仿（轻微）、甲醇（轻微、超声处理） |
| 酸度系数(pKa) | 8.95±0.10(Predicted) |
| 形态 | 晶体 |
| 颜色 | 浅黄色至厚黄色 |
| 水溶解性 | It is Soluble in ether, chloroform, and aqueous sodium hydroxide. Insoluble in water. |
| Merck | 14,3009 |
| BRN | 514910 |
| 稳定性 | 稳定的。与强氧化剂不相容。 |
| InChIKey | NZZIMKJIVMHWJC-UHFFFAOYSA-N |
| LogP | 4.59 at 25℃ |
| CAS 数据库 | 120-46-7(CAS DataBase Reference) |
| NIST化学物质信息 | 1,3-Propanedione, 1,3-diphenyl-(120-46-7) |
| EPA化学物质信息 | 1,3-Propanedione, 1,3-diphenyl- (120-46-7) |
Dibenzoylmethane (10, 20, 30, 40, 50 μM; 6 hours) treatment concentration-dependently increases the mRNA level of HO-1 but has no effect on the mRNA level of Nrf2 in HepG2 cells. Dibenzoylmethane induces HO-1 and Nrf2 protein expression, and the induction diminishes after 12 h.
Dibenzoylmethane (10, 20, 30, 40, 50 μM; 2 hours) concentration-dependently increases the phosphorylated protein levels of Erk1/2, p38MAPK, JNK, AMPK, and Akt in HepG2 cells.
Dibenzoylmethane does not show significant cytotoxicity.
Dibenzoylmethane (200, 500 mg/kg/day; ip; for three consecutive days) pretreatment significantly reduces both the area and the severity of necrosis, as well as the leukocyte infiltration, at a dose of 200 mg/kg in wild-type and Nrf2 knockout mice.
Dibenzoylmethane protectes against CCl4-induced (1:49,v/v, 10 ml/kg) liver damage in wild-type mice.
安全信息
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