酒石酸长春氟宁
| 中文名称 | 酒石酸长春氟宁 |
|---|---|
| 中文同义词 | |
| 英文名称 | Vinflunine Ditartrate |
| 英文同义词 | (2β,3β,4β,5α,12β,19α)-4-(Acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(Methoxycarbonyl)-2,6-Methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-Methoxy-1-MethylaspidosperMidine-3-carboxylic Acid Methyl Ester (2R,3R)-2,3-Dihydroxybutanedioate;Ditartrate;20',20'-Difluoro-3',4'-dihydrovinorelbine Ditartrate;4'-Deoxy-20',20'-difluoro-5'-norvincaleukoblastine Ditartrate;BMS 710485;F 12158;Javlor;Vinflunine Ditartrate |
| CAS号 | 194468-36-5 |
| 分子式 | C49H59F2N4O14 |
| 分子量 | 966.0079664 |
| EINECS号 | |
| 相关类别 | Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 194468-36-5.mol |
| 结构式 |  |
酒石酸长春氟宁 性质
| 熔点 | 244-246°C (dec) |
|---|---|
| 储存条件 | -20°C Freezer |
| 溶解度 | 可溶于DMSO（少许）、甲醇（少许） |
| 形态 | 固体 |
| 颜色 | 白色至浅米色 |
Vinflunine ditartrate 是一种长春花生物碱家族的氟化微管抑制剂。Vinflunine ditartrate 具有抗血管生成，破坏血管和抗转移的活性。Vinflunine ditartrate 可用于尿路上皮移行细胞癌，非小细胞肺癌和乳腺癌的研究。
microtubule
Vinflunine (0.01-10 μM; 45 min) induces a rapid change in endothelial cell shape: cells retracted and assumed a rounded morphology.
Vinflunine (0.01-10 μM; 1 h) disrupts newly formed capillary-like structures.
Vinflunine (0.01-10 μM; 1 h) inhibits endothelial cell motility, with an IC
50
of 0.71 μM.
Vinflunine (0.001-10 μM; 1-72 h) inhibits endothelial cell proliferation in vitro.
Vinflunine (0.08-20 mg/kg; i.v.) reduces the number of experimental liver metastases by human LS174T colon cancer cells.
Vinflunine (0.63-5 mg/kg; i.v. before and 2 d after Matrigel implantation) inhibits the bFGF-induced angiogenic response in mice in a dose-dependent manner.
| Animal Model: | Female athymic nude mice (BALB/c/Ola/Hsd-nu) were implanted LS174T cells |
| Dosage: | 0.08, 0.16, 1.25, 5, 10, 20 mg/kg |
| Administration: | I.v. on days 4, 7, 11, 14, 18 and 21 after tumour cell implantation |
| Result: | Induced a dose-dependent reduction in the number of metastatic foci at the surface of the liver and was well tolerated. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2023/03/20 | HY-B0628B | Vinflunine ditartrate | 1 mg | 4000元 | |
| 2023/03/20 | HY-B0628B | 酒石酸长春氟宁 Vinflunine ditartrate | 194468-36-5 | 5mg | 12000元 |