|
|
| | N,N-DIETHYL-2-PHENYLACETAMIDE Chemical Properties |
| Melting point | 84-86 °C | | Boiling point | 169-171 °C18 mm Hg(lit.) | | density | 1.004 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.522(lit.) | | Fp | >230 °F | | storage temp. | Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), DMSO (Slightly),Methanol (Slightly) | | pka | -0.44±0.70(Predicted) | | form | Oil | | color | Clear Colorless |
| Hazard Codes | Xn | | Risk Statements | 20/21/22 | | Safety Statements | 36 | | WGK Germany | 3 | | RTECS | AB7410000 | | Toxicity | LD50 in guinea pigs, rats, rabbits, mice (g/kg): 7, 3-4, 3.5, ~2 dermally (Rao, 1991) |
| | N,N-DIETHYL-2-PHENYLACETAMIDE Usage And Synthesis |
| Description | N, N-DIETHYL-2-PHENYLACETAMIDE is a safe and effective, low-cost and broad-spectrum repellent for personal protection against Hematophagous arthropods1. It has repellent activity against hematophagous insects including mosquitoes, black flies, horse flies, muscoid flies, rat fleas, and ticks, as well as land leeches and cockroaches.As an Insect repellents, it exert its effects through interactions with Ors (odorant receptors) and GRs (gustatory receptor neuron (GRN)) in mosquitoes. However, the detailed mechanism of action remains inconclusive.
| | Referrence |
- Kalyanasundaram, Muthuswami, and N. Mathew. "N,N-Diethyl Phenylacetamide (DEPA): A Safe and Effective Repellent for Personal Protection Against Hematophagous Arthropods." Journal of Medical Entomology 43.3(2013):518-25.
- Rao, S. S., and K. M. Rao. "Insect Repellent N, N-diethylphenylacetamide: An Update." Journal of Medical Entomology 8.3(1991):303.
- Dickens, Joseph C., and J. D. Bohbot. "Mini review: Mode of action of mosquito repellents." Pesticide Biochemistry & Physiology 106.3(2013):149-155.
| | Uses | Insect repellent. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 46, p. 1215, 1981 DOI: 10.1021/jo00319a037 | | Metabolic pathway | When rats are exposed to whole-body attack by
diethylphenylacetamide (DEPA), DEPA enters the
systemic circulation when it is inhaled, and crosses
air ? lung and lung ? blood barriers to be biodegraded
and excreted. DEPA is converted by dealkylation and
hydrolysis to the two acetamides,
ethylphenylacetamide (EPA) and phenylacetamide
(PA), and to phenylacetic acid (PhAA) which are
excreted and identified as urinary metabolites. |
| | N,N-DIETHYL-2-PHENYLACETAMIDE Preparation Products And Raw materials |
|