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Bromodiphenylmethane

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CAS:776-74-9
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  • 2023-12-26
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  • Bromodiphenylmethane is a halogenated building block. Benzhydryl group was preferred to the commoner benzyl to protect 2-nitro....
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Bromodiphenylmethane Basic information
Uses
Product Name:Bromodiphenylmethane
Synonyms:ALPHA-BROMODIPHENYLMETHANE;1,1’-(bromomethylene)bis-benzen;1,1’(Bromomethylene)bisbenzene;Methane, bromodiphenyl-;DIPHENYLMETHYL BROMIDE;BROMODIPHENYLMETHANE;[Bromo(phenyl)methyl]benzene;9,10-Dihydro-4H-Benzo[4,5] Cyclohepta[1,2-B] Thiophene
CAS:776-74-9
MF:C13H11Br
MW:247.13
EINECS:212-279-8
Product Categories:Pharmaceutical Intermediates
Mol File:776-74-9.mol
Bromodiphenylmethane Structure
Bromodiphenylmethane Chemical Properties
Melting point 35-39 °C(lit.)
Boiling point 184 °C20 mm Hg(lit.)
density 0,9 g/cm3
refractive index 1.6290 (estimate)
Fp >230 °F
storage temp. Store below +30°C.
solubility 0.45g/l
form powder to lump to clear liquid
color White to cream to yellow to orange to brown crystals or fused solid
PH2 (H2O, 20℃)(saturated aqueous solution)
Water Solubility Insoluble
Sensitive Moisture Sensitive
BRN 638544
CAS DataBase Reference776-74-9(CAS DataBase Reference)
NIST Chemistry ReferenceBenzene, 1,1'-(bromomethylene)bis-(776-74-9)
EPA Substance Registry SystemBenzene, 1,1'-(bromomethylene)bis- (776-74-9)
Safety Information
Hazard Codes C
Risk Statements 34-37
Safety Statements 26-36/37/39-45
RIDADR UN 1770 8/PG 2
WGK Germany 3
RTECS PA5350000
19-21
TSCA Yes
HazardClass 8
PackingGroup II
HS Code 29036990
MSDS Information
ProviderLanguage
Diphenylbromomethane English
SigmaAldrich English
ACROS English
ALFA English
Bromodiphenylmethane Usage And Synthesis
UsesBenzhydryl Bromide is used as a reagent in the synthesis of O-(triazolyl)methyl carbamates as a novel and potent class of fatty acid amide hydrolase (FAAH) inhibitors.
Chemical PropertiesORANGE-RED TO ORANGE-BROWN LOW MELTING SOLID
UsesBenzhydryl bromide is a halogenated building block. Benzhydryl group was preferred to the commoner benzyl to protect 2-nitrophenol in the Bartoli (vinyl Grignard) synthesis of 7-hydroxyindole. Protection was by reaction with the phenol in the presence of potassium carbonate in acetone; deprotection of the indole was by hydrogenolysis.
General DescriptionBromodiphenylmethane is a white crystalline solid. Melting point 113°F. A lachrymator. In the presence of moisture corrosive to tissue and most metals.
Air & Water ReactionsInsoluble in cold water. Decomposed by hot water to give corrosive hydrobromic acid.
Reactivity ProfileHalogenated aliphatic compounds are moderately or very reactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Materials in this group are incompatible with strong oxidizing and reducing agents. Also, they are incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.
Health HazardTOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire HazardCombustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
Safety ProfileA corrosive, irritating liquid, When heated to decomposition it emits toxic fumes of Br-. See also
Tag:Bromodiphenylmethane(776-74-9) Related Product Information
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