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Tirofiban hydrochloride monohydrate

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Products Intro:Product Name:Tirofiban Hydrochloride
CAS:150915-40-5
Purity:99% Package:1g, 5g, 25g, 100g, 1kg, bulk
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Products Intro:Product Name:Tirofiban hydrochloride Monohydrate
CAS:150915-40-5
Purity:99% Package:1Kg;5Kg;10Kg
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Products Intro:Product Name:Tirofiban Hydrochloride Hydrate
CAS:150915-40-5
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Products Intro:Product Name:Tirofiban hydrochloride Monohydrate
CAS:150915-40-5
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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Products Intro:Product Name:Tirofiban hcl Monohydrate
CAS:150915-40-5
Remarks:C14268
Tirofiban hydrochloride monohydrate Basic information
Tirofiban hydrochloride monohydrate Precautions Uses
Product Name:Tirofiban hydrochloride monohydrate
Synonyms:TIROFIBAN, HYDROCHLORIDE HYDRATE;Tirofiban HCl;TirofibanHcl142373-60-2/;N-(Butylsulfonyl)-O-[4-(4-piperidynyl)butyl]-L-tyrosine, Hydrochloride Hydrate;(2S)-2-(Butylsulfonylamino)-3-[4-[4-(4-piperidyl)butoxy]phenyl]propanoic acid hydrochloride hydrate;N-(Butylsulfonyl)-O-(4-(4-piperidinyl)butyl)-L-tyrosine monohydrochloride monohydrate;Tirofiban hydrochloride monohydrate;L-Tyrosine, N-(butylsulfonyl)-o-(4-(4-piperidinyl)butyl)-, monohydrochloride, monohydrate
CAS:150915-40-5
MF:C22H39ClN2O6S
MW:495.07
EINECS:
Product Categories:Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Cardiovascular APIs
Mol File:150915-40-5.mol
Tirofiban hydrochloride monohydrate Structure
Tirofiban hydrochloride monohydrate Chemical Properties
Melting point 135-137°C
storage temp. -20°C Freezer
solubility DMSO: >12mg/mL at warmed to 60°C
color white to beige
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-37-45
MSDS Information
Tirofiban hydrochloride monohydrate Usage And Synthesis
Tirofiban hydrochloride monohydrateTirofiban is an anti-angina drug, it is successfully developed by the United States Merck company , Patent Number is EP 478363, and in 1998 it was sold in the United States, the trade name is Aggrastat,it is clinically used in treating acute coronary syndromes, including unstable angina or non-Q-wave myocardial infarction, and percutaneous transluminal coronary angioplasty (PTCA) or atherosclerotic plaque excision patients with in combination with heparin.
Drugs currently used in clinical are mainly tirofiban hydrochloride injections under the tradename Xin Weining, it is a reversible non-peptide platelet surface glycoprotein (GP) Ⅱb/Ⅲa receptor antagonist, it can competitively inhibit combination of fibrinogen and platelet (GP) Ⅱb/Ⅲa receptor . Intravenous injection is a dose-dependent inhibition of outside human platelet aggregation, prolonged bleeding time,and thrombosis caused by ADP, collagen, arachidonic acid,thromboxane analog U46619 and thrombin.
In healthy volunteers ,they are injected in routinely recommended doses, the peak plasma concentration is similar to that of steady-state plasma concentrations during the infusion ,T1/2 is 2h. Within 0.01~25 μg/ml dose range, PPB of this product is 65%, independent of concentration. Free drug accounts for 35% in plasma, Vd is 22~42 L. In healthy volunteers, CL is 213~314 ml/min, the renal clearance rate is 39%-69% of plasma clearance.
[Usage ]
(1) tirofiban hydrochloride monohydrate in combination with heparin is used in treating acute coronary syndromes, including unstable angina or non-Q-wave myocardial infarction, and percutaneous transluminal coronary angioplasty (PTCA) or atherectomy artery surgery patients.
(2) to give this product 0.4μg/(kg · min) bolus, 300 min, followed by a maintenance dose of 0.1μg/(kg · min). Unstable angina or non-Q-wave myocardial infarction patients need an infusion of 48~108 h. Row PTCA or atherectomy arterial patients need to continue infusion 12~24 h after surgery.
The above information is edited by the chemicalbook of Tian Ye.
Precautions 1. Adverse reactions: The most common adverse reactions are fever, or bleeding complications; other visible adverse reactions are nausea, headache, rash or urticaria, systemic reactions visible is reduction in platelet count.
2. Disable: allergy to the drug, the use of tirofiban in patients with thrombocytopenia occurring, there is active bleeding or bleeding constitution history before 30 days, history of intracranial hemorrhage, nearly a month of stroke or brain hemorrhage stroke, intracranial tumors, aneurysms, arteriovenous malformations, vital organs, surgery or severe trauma requiring surgical treatment, patients with aortic dissection, pericarditis, severe hypertension.
3. caution: recent (1 year) bleeding in patients, with coagulopathy, platelet disorder, or a history of thrombocytopenia, platelet count less than 150 × 109/L patients who have a history of cerebrovascular disease (1 year) , with recent subdural extracapsular surgery, nearly a month having a major surgery or a history of severe physical trauma, dissecting aneurysm, hemorrhagic retinal diseases, chronic hemodialysis patients.
UsesAcute coronary syndrome (angina pectoris, myocardial infarction, surgery hydrant).
Tirofiban hydrochloride monohydrate is a potent non-peptide, glycoprotein IIb/IIIa inhibitor. It can prevent platelet aggregation and thrombosis.
Chemical PropertiesWhite Solid
UsesA specific nonpeptide platelet fibrinogen receptor (GPIIb/IIIa) antagonist. An antithrombotic used in the treatment of unstable angina
UsesTirofiban is a specific nonpeptide platelet fibrinogen receptor (GPIIb/IIIa) antagonist. Tirofiban is an antithrombotic used in the treatment of unstable angina.
Tirofiban hydrochloride monohydrate Preparation Products And Raw materials
Tag:Tirofiban hydrochloride monohydrate(150915-40-5) Related Product Information
L-Tyrosine 2-Butoxyethanol Diphenyl oxide Butyldiglycol PHENYL VALERATE Tramadol hydrochloride TYROSINASE FROM MUSHROOM BIOCHEMIKA, LYOPHILIZED, ≥2000 UNITS/MG TIROFIBAN HYDROCHLORIDE MONOHYDRATE TIROFIBAN-BUTYL-D9, HYDROCHLORIDE O-METHYL-L-TYROSINE HYDROCHLORIDE Tirofiban hydrochloride monohydrate Butyl acrylate Cyhalofop-butyl Tirofiban Boc-D-Tyrosine Rimantadine Phenylacetic acid Propionic acid