CHPG
| 中文名称 | CHPG |
|---|---|
| 中文同义词 | 化合物 T10809;(R,S)-CHPG,MGLU 5激动剂 |
| 英文名称 | CHPG |
| 英文同义词 | α-Amino-2-chloro-5-hydroxybenzeneacetic acid, (RS)-2-Chloro-5-hydroxyphenylglycine;(RS)-2-chloro-5-hydroxyphenylglycine α-amino-2-chloro-5-hydroxybenzeneacetic acid;α-amino-2-chloro-5-hydroxybenzeneacetic acid;(RS)-2-CHLORO-5-HYDROXYPHENYLGLYCINE;CHPG;Benzeneacetic acid, α-amino-2-chloro-5-hydroxy- |
| CAS号 | 170846-74-9 |
| 分子式 | C8H8ClNO3 |
| 分子量 | 201.61 |
| EINECS号 | |
| 相关类别 | Glutamate receptor |
| Mol文件 | 170846-74-9.mol |
| 结构式 |  |
CHPG 性质
| 沸点 | 407.3±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.531±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：≥10mg/mL |
| 形态 | 固体&_&白色固体 |
| 酸度系数(pKa) | 1.61±0.10(Predicted) |
| 颜色 | 白色 |
CHPG 是一个选择性的 mGluR5 激动剂，并且通过 TSG-6/NF-κB 途径减弱 BV2 小神经胶质细胞 SO2 诱导的氧化应激和炎症。 CHPG 通过 ERK 和 Akt 途径在体外和体内预防创伤性脑损伤 (TBI)。
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mGlu 5
|
NF-κB
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ERK
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Akt
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CHPG (10-500 µM; 24 hours) significantly increases the cell viability and decreases the LDH release after SO
2
derivatives treatment.
CHPG (0.5 mM; 30 mins ) protects BV2 cells against SO
2
-induced apoptosis.
CHPG (0.5 mM; 30 mins) treatment alone increases the expression of TSG-6 in both mRNA and protein levels.
Cell Viability Assay
| Cell Line: | BV2 microglial cells |
| Concentration: | 10, 50, 100 and 500 µM |
| Incubation Time: | 24 hours |
| Result: | Increased the cell viability. |
Apoptosis Analysis
| Cell Line: | BV2 microglial cells |
| Concentration: | 0.5 mM |
| Incubation Time: | 30 mins |
| Result: | Protected BV2 cells against SO 2 -induced apoptosis. |
Western Blot Analysis
| Cell Line: | BV2 microglial cells |
| Concentration: | 0.5 mM |
| Incubation Time: | 30 mins |
| Result: | Increased the expression of TSG-6 in both mRNA and protein levels. |
CHPG (injection; 250 nM; for 7 days) reduces significantly cerebral lesion volume.
| Animal Model: | Adult Sprague-Dawley male rats weighing 280-320 g |
| Dosage: | 250 nM |
| Administration: | Injection; for 7 days |
| Result: | Reduced significantly cerebral lesion volume. |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-101364 | CHPG | 1 mg | 1636元 | |
| 2024/04/30 | HY-101364 | CHPG CHPG | 170846-74-9 | 5mg | 3600元 |