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Lumefantrine

Lumefantrine Suppliers list
Company Name: Shenzhen Sendi Biotechnology Co.Ltd.
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Products Intro: Product Name:Lumefrantrine
CAS:82186-77-4
Purity:98% Package:319/KG
Company Name: Wuhan Fortuna Chemical Co., Ltd  Gold
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Products Intro:Product Name:Benflumetol
CAS:82186-77-4
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Products Intro:Product Name:LuMefantrine
CAS:82186-77-4
Purity:98.0%(LC&T) Package:25G,5G
Company Name: Chembest Research Laboratories Limited  
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Products Intro:Product Name:Lumefantrine (benflumetol )
CAS:82186-77-4
Purity:98% Package:5g Remarks:C11374
Company Name: TAIYUAN RHF CO.,LTD.  
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Products Intro:Product Name:LuMefantrine [BenfluMetol]
CAS:82186-77-4
Purity:98%;99% Package:1g;5g;25g;100g;250g;500g;1kg
Lumefantrine Basic information
Antimalarial drug Physical and Chemical Properties Pharmacokinetics Dosage Adverse reactions Precautions
Product Name:Lumefantrine
Synonyms:(9Z)-2,7-Dichloro-9-[(4-chlorophenyl)methylene]-α-[(dibutylamino)methyl]-9H-fluorene-4-methanol;CPG-56695;Benwuchun;Benflumentol;benflumetol;Lumefantrine;(z)-2,7-dichloro-9-[(4-chlorophenyl)methylene]-alpha-[(dibutylamino)methyl]-9h-fluorene-4-methanol;Lumefruntrine
CAS:82186-77-4
MF:C30H32Cl3NO
MW:528.94018
EINECS:
Product Categories:Pharmaceutical intermediates;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Antibiotics;API
Mol File:82186-77-4.mol
Lumefantrine Structure
Lumefantrine Chemical Properties
Melting point 129-131°C
density 1.252
storage temp. Refrigerator
solubility DMSO: ≥20mg/mL
color yellow
Merck 14,5597
CAS DataBase Reference82186-77-4(CAS DataBase Reference)
Safety Information
Hazardous Substances Data82186-77-4(Hazardous Substances Data)
MSDS Information
Lumefantrine Usage And Synthesis
Antimalarial drugBenflumetol and artemether are the widely used antimalarial drugs currently in clinical , they are the main ingredients of the well-known anti-malarial drugs called Compound artemether of Novartis ,which can kill plasmodia asexual, insecticidal rate is high, the cure rate is about 95%, but it is invalid in the pre-erythrocytic stage and gametophyte . Animal experiments suggest it is drug with micro toxicity,but the mutagenic and teratogenic tests are negative. It is mainly used for the treatment of falciparum malaria in clinical, especially for the chloroquine-resistant falciparum malaria treatment.
Physical and Chemical PropertiesYellow crystalline powder, bitter almond smell, tasteless. Soluble in chloroform, slightly soluble in acetone, almost insoluble in alcohol, melting point of 125~131 ℃.
Pharmacokinetics Oral absorption is slow, elimination is also slow,it can stay a long time in the body . Tmax after administration is 4~5h, t1/2 is 24~72h.
Dosage4d therapy: Adults eat 800mg at draught on the first day ,on day 2, 3, 4, each 400mg at draught; children daily take 8mg/kg at draught, and continue for 4d, the first dose is doubled, but the first dose does not exceed the maximum dose of 0.6g.
The above information is edited by the chemicalbook of Tian Ye.
Adverse reactions There are no significant adverse reactions, a small number of patients suffer with electrocardiographic Q~T interval transient mild extending.
Precautions Patients with heart, kidney dysfunction,should use with caution. After symptoms are controlled in patients with malignant malaria and the parasite is killed in the pre-erythrocytic stage ,primaquine can be used to kill gametocytes. It is saved in the dark, sealed, cool and dry place.
Chemical PropertiesYellow Solid
UsesInhibits hemozoin formation. Antimalarial
UsesA drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human.
DefinitionChEBI: Lumefantrine is an antimalarial drug used in combination with artemether for the treatment of multi-drug resistant strains of falciparum malaria.
Lumefantrine Preparation Products And Raw materials
Tag:Lumefantrine(82186-77-4) Related Product Information
Lumefantrine Methylene Blue Dichlorodiphenylsilane Acetonitrile 4,4'-Diphenylmethane diisocyanate Sulfamic acid Diethylene glycol dibenzoate Basic Violet 1 Polyol benzoate Dichloroethane EC 2.6.1.2 4-Acetamidophenol 4-(DICYANOMETHYLENE)-2-METHYL-6-(JULOLIDIN-4-YL-VINYL)-4H-PYRAN Methanol Methyl acrylate Methyl Methylparaben Dichloromethylphenylsilane