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| | Bifemelane HCl Basic information |
| Product Name: | Bifemelane HCl | | Synonyms: | Bifemelane HCl;Bifemelane hydrochloride;Bifemelan hydrochloride;MEAHDXWXNNDSAK-UHFFFAOYSA-N;4-(2-Benzylphenoxy)-N-methylbutan-1-amine hydrochloride;inhibit,Inhibitor,Monoamine Oxidase,MAO-A,MAO,MCI 2016,Bifemelane hydrochloride,antidepressant,Bifemelane,monoamine,MCI-2016,MCI2016,oxidase,MAO-B | | CAS: | 62232-46-6 | | MF: | C18H23NO.ClH | | MW: | 305.847 | | EINECS: | | | Product Categories: | | | Mol File: | 62232-46-6.mol |  |
| | Bifemelane HCl Chemical Properties |
| Melting point | 117-121° | | solubility | Soluble to 100 mM in water and to 100 mM in DMSO | | form | Powder |
| Toxicity | LD50 in mice, rats (mg/kg): 1000, 1080 orally; 173, 130 i.p. (Tobe, 1981) |
| | Bifemelane HCl Usage And Synthesis |
| Description | Bifemelane is a nootropic reported to have antianoxic, anti-ischemic and memory
enhancing activities. In man, bifemelane appears to increase cerebral blood flow, while in
rodents it reverses scopolamine-induced dementia. Bifemelane has an added adrenergic
component reportedly arising from norepinephrine uptake inhibition. | | Originator | Mitsubishi; Eisai (Japan) | | Uses | Bifemelane Hydrochloride, is an antidepressant MAO inhibitor. It has also been reported to protect neural tissues against ischemic damage and age-related neurodegeneration. | | Manufacturing Process | N-Methyl-4-[2-(phenylmethyl)phenoxy]-1-butanamine was prepared from 2-
(5-bromopentyloxy)diphenylmethane and of methylamine in ethanol is at
50°C in a sealed tube (heating for 3 hours). Ethanol and excess methylamine
are distilled in vacuo, 2 N NaOH aqueous solution is added, and the reaction
product is extracted with ether. Dry hydrogen chloride gas is passed into the
ether solution, and the precipitate collected by filtration. Recrystallization from
ethanol-ether gives N-methyl-4-[2-(phenylmethyl)phenoxy]-1-butanamine
hydrochloride, m.p. 87.5-89.5°C. | | Brand name | Alnert; Celeport | | Therapeutic Function | Antidepressant, Antiulcer, Nootropic | | Hazard | Moderately toxic by ingestion. | | storage | Desiccate at RT |
| | Bifemelane HCl Preparation Products And Raw materials |
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