4,6-亚乙基-alpha-D-葡萄糖

4,6-亚乙基-alpha-D-葡萄糖

中文名称4,6-亚乙基-alpha-D-葡萄糖
中文同义词4,6-亚乙基-Α-D-葡萄糖;4,6-O-亚乙基-Α-D-吡喃葡萄糖;4,6-O-亚乙基-Α4,6-O-亚乙基-Α-D-吡喃葡糖;4,6-O-亚乙基-Α-D-葡糖;4,6-O-亚乙基-Α-D-葡萄糖;4,6-亚乙基-alpha-D-葡萄糖;4 6 0-乙缩醛-D-葡萄糖
英文名称4,6-O-Ethylidene-alpha-D-glucose
英文同义词(2R,3R)-2,3-dihydroxy-3-((4R,5R)-5-hydroxy-2-methyl-1,3-dioxan-4-yl)propanal;(4aR,6S,7R,8R,8aS)-2-Methylhexahydropyrano[3,2-d][1,3]dioxine-6,7,8-triol;(4AR,7R,8R,8aS)-2-Methylhexahydropyrano-[3,2-d][1,3]dioxine-6,7,8-triol;NSC 89726;-D-glucopyranose;4,6-O-Ethylidene-α4,6-O-ETHYLIDENE-A-D-GLUCOSE;4,6-O-ETHYLIDENE-ALPHA-D-GLUCOPYRANOSE
CAS号13224-99-2
分子式C8H14O6
分子量206.19
EINECS号236-198-2
相关类别单糖;Carbohydrate Synthesis;Specialty Synthesis;Monosaccharides;Sugars;Sugars, Carbohydrates & Glucosides;Biochemistry;Glucose;O-Substituted Sugars
Mol文件13224-99-2.mol
结构式4,6-亚乙基-alpha-D-葡萄糖 结构式

4,6-亚乙基-alpha-D-葡萄糖 性质

熔点168-170 °C(lit.)
沸点386.6±42.0 °C(Predicted)
密度1.446±0.06 g/cm3(Predicted)
闪点>110°(230°F)
溶解度乙醇、水
酸度系数(pKa)12.01±0.70(Predicted)
形态粉末
颜色白色至类白色
水溶解性almost transparency
LogP0.54
CAS 数据库13224-99-2(CAS DataBase Reference)

4,6-亚乙基-alpha-D-葡萄糖 用途与合成方法

4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose) 是一种葡萄糖衍生物,是竞争性的葡萄糖转运蛋白 1 (GLUT1) 面部结合部位抑制剂,对野生型 2-脱氧-D-葡萄糖转运的 Ki 值为 12 mM。

GLUT1

Human Endogenous Metabolite

4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose) shows poor affinity for malarial hexose transporter (PfHT1; K i >50 mM). 4,6-O-ethylidene-α-D-glucose inhibits wild-type transport with a K i of approximately 12 mM, but this is increased to greater than 120 mM in the Gln282-Leu mutant.
4,6-O-ethylidene-α-D-glucose inhibits glucose exit competitively but its penetration into human red cells is unaffected by glucose in the medium. The potentiation of the development of FDNB inhibition by sugars in the incubating medium is absent when 4,6-O-ethylidene-α-D-glucose is used and there is a slight protective action. 4,6-O-ethylidene-α-D-glucose penetrates human red cells by simple diffusion supported by its penetration of guinea-pig red cells at similar rates, by the occurrence of osmotic haemolysis in isosmotic solutions which is unaffected by copper ions and by the relatively high ether/water partition of the compound.

安全信息

安全说明24/25
WGK Germany3
海关编码29400090

MSDS信息

提供商 语言
英文
更新日期产品编号产品名称CAS号包装价格
2024/01/25HY-N74334,6-亚乙基-alpha-D-葡萄糖
4,6-O-Ethylidene-α-D-glucose
13224-99-250mg1000元
2024/01/25HY-N74334,6-亚乙基-alpha-D-葡萄糖
4,6-O-Ethylidene-α-D-glucose
13224-99-210mM * 1mLin DMSO1100元

4,6-亚乙基-alpha-D-葡萄糖 上下游产品信息

"4,6-亚乙基-alpha-D-葡萄糖"相关产品信息
羟乙基纤维素 二乙烯三胺 一水葡萄糖 谷物或玉米糖浆 羟基乙叉二膦酸 四乙烯五胺 乙基麦芽酚 葡萄糖氧化酶 己烯雌酚 D-无水葡萄糖 N-亚硝基二乙胺 液体葡萄糖 甲基2,3-二-O-苯甲酰基-4,6-O-苯亚甲基-Α-D-吡喃葡萄糖苷 甲基-4,6-O-亚苄基-Α-D-吡喃葡糖苷 4,6-亚乙基-alpha-D-葡萄糖
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