二氢丹参酮 I
| 中文名称 | 二氢丹参酮 I |
|---|---|
| 中文同义词 | DIHYDROTANSHINONE I 二氢丹参酮I;二氢丹参酮I(标准品);丹参酮 二水合物;二氢丹参酮 Ⅰ, 来源于丹参;二氢丹参酮 I;二氢丹参酮 I, 来源于丹参;DIHYDROTANSHINONE I 二氢丹参酮I 标准品;二氢丹参酮Ⅰ对照品, |
| 英文名称 | Dihydrotanshinone I |
| 英文同义词 | (-)-1,2-Dihydro-1,6-dimethylphenanthro[1,2-b]furan-10,11-dione;1,6-Dimethyl-1,2,10,11-tetrahydrophenanthro[1,2-b]furan-10,11-dione;4,17-Dimethyl-15-oxagona-1,3,5(10),6,8,13-hexene-11,12-dione;Dihydrotanshinone Ⅰ, froM Salvia Miltiorrhiza;(1R)-1,6-diMethyl-1,2-dihydronaphtho[1,2-g][1]benzofuran-10,11-dione;Dihydrotanshinone I;15,16-Dihydrotanshine I;1,6-DiMethyl-1,2-dihydrophenanthro[1,2-b]furan-10,11-dione |
| CAS号 | 87205-99-0 |
| 分子式 | C18H14O3 |
| 分子量 | 278.3 |
| EINECS号 | |
| 植物来源 | 丹参 |
| 相关类别 | 植提标准品;对照品;植物提取物;中药对照品;标准品;对照品,标准品;分析试剂标准品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;标准品-中药标准品;标准品 -中药标准品;其它天然产物;标准品-对照品;丹参系列 |
| Mol文件 | 87205-99-0.mol |
| 结构式 |  |
二氢丹参酮 I 性质
| 熔点 | 214.0 to 218.0 °C |
|---|---|
| 沸点 | 479.2±45.0 °C(Predicted) |
| 密度 | 1.32±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 乙醇：可溶1mg/mL，澄清，橙色至红色 |
| 形态 | 粉末 |
| 颜色 | 红色 |
| 最大波长(λmax) | 239nm(lit.) |
In lipopolysaccharide (LPS)-stimulated human umbilical vein endothelial cells (HUVECs), DHT (10 nM) decreases lectin-like ox-LDL receptor-1 (LOX-1) and NADPH oxidase 4 (NOX4) expression, reactive oxygen species (ROS) production, NF-κB nuclear translocation, ox-LDL endocytosis and monocytes adhesion. Dihydrotanshinone I induces caspase dependent apoptosis induced in HCT116 cells. Dihydrotanshinone I induces concentration and ROS dependent caspase activation. Apoptosis induced by Dihydrotanshinone I is completely prevented by Z-VAD-fmk. Apoptosis induced by Dihydrotanshinone I is significantly inhibited by pretreatment of Z-LEHD-fmk but only is partially inhibited by Z-IETD-fmk. Apoptosis induced by Dihydrotanshinone I is significantly increased by caspase-2 knockdown.
DHT (10 and 25 mg/kg) significantly attenuates atherosclerotic plaque formation, alteres serum lipid profile, decreases oxidative stress and shrinks necrotic core areas in ApoE -/- mice. DHT dramatically inhibits the enhanced expression of LOX-1, NOX4, and NF-κB in aorta. Dihydrotanshinone I (1, 2, 4 mg/kg) treatment can improve cardiac function, reduce infarct size, ameliorate the variations in myocardial zymogram and histopathological disorders, decrease 20-HETE generation, and regulate apoptosis-related protein in myocardial ischemia-reperfusion rats.
药理药效:具有抗菌活性。对金黄色葡萄球菌209 P 的抑菌卷直径为23mm(滤纸片法), 对人型结核杆菌 H↓37RV 最低抑菌浓度为1.5μg/ml。对溶血性链球菌也有一定抑制作用
安全信息
| 危险品标志 | Xn,N |
|---|---|
| 危险类别码 | 22-50 |
| 安全说明 | 61 |
| 危险品运输编号 | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| RTECS号 | SF8282630 |
| 海关编码 | 29329990 |
| 毒害物质数据 | 87205-99-0(Hazardous Substances Data) |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-N0360 | Dihydrotanshinone I | 5 mg | 625元 | |
| 2024/01/25 | HY-N0360 | 二氢丹参酮 I Dihydrotanshinone I | 87205-99-0 | 10mg | 1000元 |