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Semicarbazide hydrochloride

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CAS:563-41-7
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Semicarbazide hydrochloride manufacturers

Semicarbazide hydrochloride Basic information
Product Name:Semicarbazide hydrochloride
Synonyms:amidoureahydrochloride;semicarbazide,monohydrochloride;semicarbazidechloride;CARBAMYLHYDRAZINEHCL;Semicarbazide-13CHCl;Semicarbaside;SIMICARBAZIDECHLORHYDRATE;Semicalbazide Chlorhydrate
CAS:563-41-7
MF:CH6ClN3O
MW:111.53
EINECS:209-247-0
Product Categories:Building Blocks;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks;Ureas;API;Amines, Metabolites & Impurities;Amines;Metabolites & Impurities;Bases & Related Reagents;Inhibitors;Nucleotides
Mol File:563-41-7.mol
Semicarbazide hydrochloride Structure
Semicarbazide hydrochloride Chemical Properties
Melting point 175-177 °C (dec.)(lit.)
Boiling point 394.09℃[at 101 325 Pa]
density 1.2908 (rough estimate)
vapor pressure 0-0Pa at 25℃
refractive index 1.4480 (estimate)
storage temp. Store at +15°C to +25°C.
solubility H2O: 0.1 g/mL at 20 °C, clear, colorless
form Crystalline Powder and/or Chunks
color White
PH1.5 (100g/l, H2O, 20℃)
Water Solubility 100 g/L (15 ºC)
Merck 14,8444
BRN 3593642
Stability:Stable. Incompatible with strong oxidizing agents, strong bases.
InChIKeyXHQYBDSXTDXSHY-UHFFFAOYSA-N
LogP-4.99--1.9 at 20℃
CAS DataBase Reference563-41-7(CAS DataBase Reference)
IARC3 (Vol. 12, Sup 7) 1987
EPA Substance Registry SystemSemicarbazide hydrochloride (563-41-7)
Safety Information
Hazard Codes Xn,T
Risk Statements 22-40-36/38-25-45-23/24/25
Safety Statements 24/25-22-45-53
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS VT3500000
TSCA Yes
HS Code 2928 00 90
HazardClass 6.1
PackingGroup III
Hazardous Substances Data563-41-7(Hazardous Substances Data)
ToxicityLD50 orally in Rabbit: 123 mg/kg
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
Semicarbazide hydrochloride Usage And Synthesis
Chemical PropertiesWhite Solid
Chemical PropertiesSemicarbazide hydrochloride is a white crystalline solid.
UsesInhibitor of enzyme. Hypotensive
UsesSemicarbazide hydrochloride is used as urease substrate and MAO inhibitor. Derivatizing agent for carbonyl compounds as their semicarbazones which produces crystalline compounds with characteristic melting points. Also used in heterocyclic synthesis. Semicarbazone formation has been used to separate carbonyl compounds from mixtures by adsorption onto silica gel from a hydrocarbon solution. Regeneration is by hydrolysis with oxalic acid.
UsesA metabolite of Nitrofuran.
DefinitionChEBI: Semicarbazide hydrochloride is an organic molecular entity.
HazardToxic by ingestion. Questionable carcino- gen.
Health HazardSemicarbazide hydrochloride is a chemical reagent, and an indicator for its metabolic parent nitrofurazone, a veterinary drug that has been banned for use in livestock production in the European Union and the U.S. amongst other jurisdictions.
After Semicarbazide hydrochloride ingestion, experimental animals have developed tremors, ataxia, equilibrium difficulties, and convulsions. Its proposed mechanism of action is by binding to cytosine residues in RNA, to deoxycytosine residues in DNA and to cytosine and deoxycytosine nucleosides.
Semicarbazide hydrochloride has an oral LD50 of 225mg/kg in mice and 123 mg/kg in the rat. Some studies suggest that Semicarbazide hydrochloride is a mutagen, an animal carcinogen and a teratogen.
Due to the lack of data in humans and overall limited evidence of carcinogenicity in animals, semicarbazide hydrochloride was classified as an IARC Group 3 agent: not classifiable as to its carcinogenicity to humans. Due to its equivocal carcinogenic and mutagenic properties, when handling Semicarbazide hydrochloride and animals treated with Semicarbazide hydrochloride, it is imperative to take caution and adhere to the following guidelines to minimize exposure and the effects of exposure during normal and emergency situations.
Flammability and ExplosibilityNot classified
Safety ProfilePoison by ingestion and intraperitoneal routes. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic and teratogenic data. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl
Potential ExposureThis material is used as a reagent for ketones and aldehydes with which it affords crystalline compounds having characteristic freezing/melting points. Also used in isolation of hormones and certain fractions from essential oils.
ShippingUN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Purification MethodsCrystallise the salt from aqueous 75% EtOH and dry it under vacuum over CaSO4. Alternatively crystallise it from a mixture of 3.6 mole % MeOH and 6.4 mole % of water. [Kovach et al. J Am Chem Soc 107 7360 1985.] IR: 700, 3500 cm-1 [Ingersoll et al. Org Synth Coll Vol I 485 1941, Davison & Christie J Chem Soc 3389 1955, Thiele & Stange Chem Ber 27 33 1894, pK: Bartlett J Am Chem Soc 54 2853 1923]. The free base crystallises as prisms from absolute EtOH, m 96o. [Curtius & Heidenreich Chem Ber 27 55 1894, Beilstein 3 IV 177.] TOXIC ORALLY, possible CARCINOGEN and TERATOGEN.
IncompatibilitiesIncompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. May ignite combustible materials (wood, oil, paper).
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