| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:Valeryl Salicylate
CAS:64206-54-8
Purity:>99% Package:100mg
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| Company Name: |
Guangzhou Isun Pharmaceutical Co., Ltd
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| Tel: |
020-39119399 18927568969 |
| Email: |
isunpharm@qq.com |
| Products Intro: |
Product Name:Valeryl Salicylate
CAS:64206-54-8
Purity:98% (HPLC) Package:5MG; 25MG; 100MG; 1G
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:Valeroyl Salicylate
CAS:64206-54-8
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| | 2-VALERYLOXYBENZOIC ACID Basic information |
| Product Name: | 2-VALERYLOXYBENZOIC ACID | | Synonyms: | VSA;VALERYL SALICYLATE;VALERYLSALICYLIC ACID;VALEROYL SALICYLATE;salicylicacid,valerate;2-[(1-OXOPENTYL)OXY]-BENZOIC ACID;2-VALERYLOXYBENZOIC ACID;2-Valeryloxybenzoic acid, Valerylsalicylic acid, vsa | | CAS: | 64206-54-8 | | MF: | C12H14O4 | | MW: | 222.24 | | EINECS: | | | Product Categories: | | | Mol File: | 64206-54-8.mol |  |
| | 2-VALERYLOXYBENZOIC ACID Chemical Properties |
| Melting point | 86-87 °C(lit.) | | Boiling point | 357.6±25.0 °C(Predicted) | | density | 1.175±0.06 g/cm3(Predicted) | | storage temp. | Room temperature | | solubility | DMSO: 24 mL/mL | | pka | 3.01±0.36(Predicted) | | form | A crystalline solid | | color | white |
| | 2-VALERYLOXYBENZOIC ACID Usage And Synthesis |
| Uses | Valeryl salicylate is a selective inhibitor of Cox-1. | | Definition | ChEBI: A valerate ester that is salicylic acid in which the phenolic hydrogen is replaced by a valeryl (pentanoyl) group. | | Biological Activity | valeroyl salicylate is an irreversible and selective inhibitor of cyclooxygenase-1 (cox-1) with ic50 values of 0.8 and 15 mm for ovine cox-1 and -2, respectively [1].cyclooxygenase (cox), also known as prostaglandin-endoperoxide synthase (ptgs, pghs), is an enzyme responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin. cox-1 is the constitutive isoform and is mainly responsible for the synthesis of cytoprotective prostaglandins in the gastrointestinal tract (gi) and of the proaggregatory thromboxane in blood platelets. cox-2 is inducible and short-lived that is stimulated by endotoxin, cytokines, and mitogens. cox-2 plays important roles in prostaglandin biosynthesis in inflammatory cells the central nervous system [1][2].valeroyl salicylate is an irreversible and selective inhibitor of cyclooxygenase-1 (cox-1) with ic50 values of 0.8 and 15 mm for ovine cox-1 and -2, respectively. in cos-1 cells expressing either cox-1 or -2, 500 μm of valeroyl salicylate inhibited human cox-1 and -2 by 85% and 15%, respectively. the half-lives for inactivation of human recombinant cox-1 in the presence of 500 μm valeroyl salicylate was 12 minutes [2]. | | references | [1]. johnson jl, wimsatt j, buckel sd, et al. purification and characterization of prostaglandin h synthase-2 from sheep placental cotyledons. arch biochem biophys. 1995 dec 1;324(1):26-34.
[2]. bhattacharyya dk, lecomte m, dunn j, et al. selective inhibition of prostaglandin endoperoxide synthase-1 (cyclooxygenase-1) by valerylsalicylic acid. arch biochem biophys. 1995 feb 20;317(1):19-24. |
| | 2-VALERYLOXYBENZOIC ACID Preparation Products And Raw materials |
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