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Ebastine

Ebastine Suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: +86 (0)571-855 867 18
Email: sales@capotchem.com
Products Intro: Product Name:Ebastine
CAS:90729-43-4
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: J & K SCIENTIFIC LTD.  
Tel:400-666-7788 +86-10-82848833
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Products Intro:Product Name:Ebastine
CAS:90729-43-4
Purity:98.0%(LC&T) Package:1G,5G
Company Name: Meryer (Shanghai) Chemical Technology Co., Ltd.  
Tel:+86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
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Products Intro:Product Name:Ebastine
CAS:90729-43-4
Purity:>98.0%(LC)(T) Package:1g;5g Remarks:E0925
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
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Products Intro:Product Name:Ebastine
CAS:90729-43-4
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
Company Name: Chembest Research Laboratories Limited  
Tel:+86(0)21-20908456
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Products Intro:Product Name:Ebastine
CAS:90729-43-4
Remarks:C13601
Ebastine Basic information
Description References
Product Name:Ebastine
Synonyms:4'-(1,1-Dimethylethyl)-γ-[4-(diphenylmethoxy)piperidin-1-yl]butyrophenone;4'-tert-Butyl-γ-[4-(diphenylmethoxy)piperidino]butyrophenone;Ebastel-OD;LAS-90;IMp. A (EP): DiphenylMethanol (Benzhydrol);Ebastine Impurity;1-butanone,1-(4-(1,1-dimethylethyl)phenyl)-4-(4-(diphenylmethoxy)-1-piperidiny;4’-tert-butyl-4-(4-(diphenylmethoxy)piperidino)butyrophenone
CAS:90729-43-4
MF:C32H39NO2
MW:469.66
EINECS:
Product Categories:Inhibitors;Active Pharmaceutical Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:90729-43-4.mol
Ebastine Structure
Ebastine Chemical Properties
Melting point 80-82°C
storage temp. Room temp
solubility Slightly soluble in chloroform, methanol.
color white
CAS DataBase Reference90729-43-4(CAS DataBase Reference)
Safety Information
RTECS EL8140000
MSDS Information
Ebastine Usage And Synthesis
DescriptionEbastine belongs to an effective second generation histamine H1 receptor antagonist. One important property of it is that it doesn’t penetrate the blood brain barrier. Therefore, it is capable of blocking the H1 receptor in peripheral tissue without having some specific side effects such as sedation and drowsiness. Ebastine is mainly applied for the treatment of allergic rhinitis, pruritus as well as acting as an alternative drug in Decongestant. Upon entering into the human body, it can subject to the action of hepatic cytochrome P450 3A4 to be converted to an active carboxylic acid metabolite, carebastine. The later one is the major active form in vivo. Under certain range, it can inhibit T cell proliferation and the production of Th2-type pro-inflammatory cytokines through macrophages. Ebastine generally has a high safety property without causing cognitive/psychomotor impairment and sedation, like placebo. However, it can cause side effects such as inflammation of the air-cavities around nose, sore throat, indigestion, nausea, headache, and abdominal pain.
Referenceshttps://pubchem.ncbi.nlm.nih.gov/compound/3191#section=Top
http://www.tabletwise.com/medicine/ebastine/side-effects
http://www.druginfosys.com/drug.aspx?drugcode=897&type=1
Chemical PropertiesWhite to Off-White Powder
UsesA nonsedating type histamine H1-receptor antagonist. Antihistaminic
Ebastine Preparation Products And Raw materials
Raw materials4-Hydroxypiperidine -->Bromodiphenylmethane
Tag:Ebastine(90729-43-4) Related Product Information
Cetirizine Loratadine Desalkyl Ebastine-d5 EBASTINE IMPURITY D Ebastine Base / Fumerate 1-[3-(4-TERT-BUTYLBENZOYL)-PROPYL]-4-HYDROXYPIPERIDINE/INTERMEDIATE OF EBASTINE EBASTINE FUMERATE Ebastine-D5 Carebastine EBASTINE FUMARATE Methyl 2-(4-(4-chlorobutanoyl)phenyl)-2-methylpropanoate Ebastine Chlorodiphenylphosphine Dichlorodiphenylsilane 1,3-Diphenyl-2-thiourea DI-TERT-BUTYL ETHER 1,5-Diphenylcarbazide (+-) 1-BROMO-2-METHYLBUTANE 95